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Titolo:
THE LECTIN-LIKE NK CELL-RECEPTOR LY-49A RECOGNIZES A CARBOHYDRATE-INDEPENDENT EPITOPE ON ITS MHC CLASS-I LIGAND
Autore:
MATSUMOTO N; RIBAUDO RK; ABASTADO JP; MARGULIES DH; YOKOYAMA WM;
Indirizzi:
WASHINGTON UNIV,SCH MED,HOWARD HUGHES MED INST,DIV RHEUMATOL ST LOUISMO 63110 WASHINGTON UNIV,SCH MED,HOWARD HUGHES MED INST,DIV RHEUMATOL ST LOUISMO 63110 NCI,LAB IMMUNE CELL BIOL BETHESDA MD 20892 INST PASTEUR,DEPT IMMUNOL F-75724 PARIS FRANCE NATL INST HLTH,IMMUNOL LAB BETHESDA MD 20892
Titolo Testata:
Immunity
fascicolo: 2, volume: 8, anno: 1998,
pagine: 245 - 254
SICI:
1074-7613(1998)8:2<245:TLNCLR>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAJOR HISTOCOMPATIBILITY COMPLEX; NATURAL-KILLER-CELLS; MONOCLONAL-ANTIBODIES; KD/DD RECOMBINANTS; ANIMAL LECTINS; BINDING-SITE; T-CELLS; MOLECULES; ANTIGEN; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
55
Recensione:
Indirizzi per estratti:
Citazione:
N. Matsumoto et al., "THE LECTIN-LIKE NK CELL-RECEPTOR LY-49A RECOGNIZES A CARBOHYDRATE-INDEPENDENT EPITOPE ON ITS MHC CLASS-I LIGAND", Immunity, 8(2), 1998, pp. 245-254

Abstract

The mouse NK inhibitory Ly-49A receptor specifically interacts with apeptide-induced conformational determinant on its MHC class I ligand,H-2D(d). In addition, it binds the polysaccharide fucoidan, consistent with its C-type lectin homology and the hypothesis that Ly-49A interacts with carbohydrates on D-d. Herein, however, we demonstrate that Ly-49A recognizes D-d mutants lacking N-glycosylation. Fucoidan competes for binding with anti-Ly-49A antibodies that inhibit Ly-49A-D-d interaction, and blocks apparent Ly-49A binding to unglycosylated D-d. We confirm that Ly-49A recognizes the alpha 1 and amino-terminal alpha 2 domains of D-d by analysis of recombinant H-2K(d)-H-2D(d) molecules. These studies indicate that Ly-49A recognizes carbohydrate-independent epitope(s) on D-d and suggest that Ly-49A has two distinct ligands, carbohydrate and MHC class I.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 21:48:28