Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
IN-VIVO SYNTHESIS OF TUMOR-NECROSIS-FACTOR-ALPHA IN HEALTHY HUMANS AFTER LIVE YELLOW-FEVER VACCINATION
Autore:
HACKER UT; JELINEK T; ERHARDT S; EIGLER A; HARTMANN G; NOTHDURFT HD; ENDRES S;
Indirizzi:
UNIV MUNICH,KLINIKUM INNENSTADT,MED KLIN,DIV CLIN PHARMACOL,ZIEMSSENSTR 1 D-80336 MUNICH GERMANY UNIV MUNICH,KLINIKUM INNENSTADT,MED KLIN,DIV CLIN PHARMACOL D-80336 MUNICH GERMANY UNIV MUNICH,KLINIKUM INNENSTADT,MED KLIN,DEPT TROP MED & INFECT DIS D-80336 MUNICH GERMANY
Titolo Testata:
The Journal of infectious diseases
fascicolo: 3, volume: 177, anno: 1998,
pagine: 774 - 778
SICI:
0022-1899(1998)177:3<774:ISOTIH>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRANCISELLA-TULARENSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
U.T. Hacker et al., "IN-VIVO SYNTHESIS OF TUMOR-NECROSIS-FACTOR-ALPHA IN HEALTHY HUMANS AFTER LIVE YELLOW-FEVER VACCINATION", The Journal of infectious diseases, 177(3), 1998, pp. 774-778

Abstract

Most knowledge about the synthesis of human tumor necrosis factor (TNF)-alpha and its regulation derives from in vitro studies. The hypothesis that the syndrome of malaise, myalgia, and low fever observed after a vaccination with live attenuated yellow fever virus could be associated with increased synthesis of TNF was investigated. Plasma samplesof 15 healthy subjects taken before and until day 2 (until day 11 in 5 of these subjects) after yellow-fever vaccination, showed a significant increase of plasma TNF concentration on day 2 after vaccination and a second peak on day 7. Interleukin-1 receptor antagonist (IL-1ra) concentration was significantly elevated in all subjects on day 2 aftervaccination. In a control group receiving non-live vaccinations, TNF and IL-1ra concentrations were unchanged. Thus, yellow fever vaccination represents a routine medical intervention that results in a reproducible increase in the plasma concentration of TNF and secondary cytokines. This may serve as a unique model for the study of the regulation of TNF synthesis in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:59:01