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Titolo:
COADMINISTRATION OF CITALOPRAM AND CLOZAPINE - EFFECT ON PLASMA CLOZAPINE LEVELS
Autore:
TAYLOR D; ELLISON Z; SHAW LE; WICKHAM H; MURRAY R;
Indirizzi:
BETHLEM & MAUDSLEY NHS TRUST,DENMARK HILL LONDON SE5 8AZ ENGLAND
Titolo Testata:
International clinical psychopharmacology
fascicolo: 1, volume: 13, anno: 1998,
pagine: 19 - 21
SICI:
0268-1315(1998)13:1<19:COCAC->2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEROTONIN REUPTAKE INHIBITORS; SERUM LEVELS; NORCLOZAPINE;
Keywords:
CLOZAPINE; CITALOPRAM; CYTOCHROMES P4501A2/2D6; INTERACTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
D. Taylor et al., "COADMINISTRATION OF CITALOPRAM AND CLOZAPINE - EFFECT ON PLASMA CLOZAPINE LEVELS", International clinical psychopharmacology, 13(1), 1998, pp. 19-21

Abstract

Antidepressants are frequently used in the treatment of depressive symptoms associated with schizophrenia. In patients taking clozapine, choice of antidepressant is complicated by additive pharmacodynamic effects and by pharmacokinetic interactions. We predicted that citalopram would not elevate plasma clozapine levels when the two drugs were co-administered because it does not inhibit the relevant enzyme systems. In this preliminary study of five patients given citalopram and clozapine there was no overall change in mean clozapine levels. Based on thislimited evidence, citalopram might be the antidepressant of choice inpatients taking clozapine. (C) 1998 Rapid Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 17/01/20 alle ore 20:27:36