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Titolo:
COMPARATIVE GENOMIC IN-SITU HYBRIDIZATION DISCLOSES CHROMOSOMAL COPY NUMBER CHANGES IN A TRANSPLANTED BRAIN-TUMOR LINE OF THE RAT (RATTUS-NORVEGICUS)
Autore:
KAPPLER R; SCHLEGEL J; ROMANAKIS K; MENNEL HD; SCHERTHAN H;
Indirizzi:
UNIV KAISERSLAUTERN,DEPT HUMAN BIOL & HUMAN GENET,POB 3049 D-67653 KAISERSLAUTERN GERMANY UNIV KAISERSLAUTERN,DEPT HUMAN BIOL & HUMAN GENET D-67653 KAISERSLAUTERN GERMANY UNIV MARBURG,MED CTR,DEPT NEUROPATHOL D-35043 MARBURG GERMANY
Titolo Testata:
Mammalian genome
fascicolo: 3, volume: 9, anno: 1998,
pagine: 193 - 197
SICI:
0938-8990(1998)9:3<193:CGIHDC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN GLIOMAS; SOLID TUMORS; GENE; DNA; AMPLIFICATION; ABNORMALITIES; ONCOGENES; CANCER; LOSSES; GAINS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
R. Kappler et al., "COMPARATIVE GENOMIC IN-SITU HYBRIDIZATION DISCLOSES CHROMOSOMAL COPY NUMBER CHANGES IN A TRANSPLANTED BRAIN-TUMOR LINE OF THE RAT (RATTUS-NORVEGICUS)", Mammalian genome, 9(3), 1998, pp. 193-197

Abstract

We investigated chromosomal copy number changes in ethylnitrosourea-induced and serially transplanted gliomas of the rat by flow cytometry and Comparative Genomic in situ Hybridization (CGH). CGH analysis of aprimary and four transplanted tumors revealed several genomic aberrations, including whole chromosome and subchromosomal gains and losses. Gains involved rat Chromosomes (RNO) 2, 3, 4, 5, 7, 9, 11, 12, 13, andY, whereas losses affected RNO5, 13, 20, and Y. The primary tumor exhibited gain of RNO2q31qter and gain of RNO4. While gain of RNO2 was seen in nearly all investigated passages, gain of RNO4 was apparent in the primary tumor and in passage 2 and 5 tumors. Chromosomal alterations detected as single events were restricted to the transplanted tumorsand included gain of RNO3q11, 3q41qter, 5q36, 7q34qter, 9q37, 11q, and Y, and loss of RNO5, 13, and 20q. Flow cytometry disclosed differentaneuploid cell clones in the tumors investigated. The results are discussed in analogy to findings in human glial tumors.

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Documento generato il 23/09/20 alle ore 09:27:54