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Titolo:
SYNTHESIS, PHARMACOLOGY AND THERAPEUTIC POTENTIAL OF 10-METHOXYPYRAZINO[1,2-A]INDOLES, PARTIAL AGONISTS AT THE 5HT(2C) RECEPTOR
Autore:
BOS M; JENCK F; MARTIN JR; MOREAU JL; MUTEL V; SLEIGHT AJ; WIDMER U;
Indirizzi:
F HOFFMANN LA ROCHE & CO LTD,DIV PHARMA,PRECLIN CNS RES CH-4070 BASELSWITZERLAND
Titolo Testata:
European journal of medicinal chemistry
fascicolo: 3, volume: 32, anno: 1997,
pagine: 253 - 261
SICI:
0223-5234(1997)32:3<253:SPATPO>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED ANHEDONIA MODEL; DEPRESSION; RATS;
Keywords:
PYRAZINOINDOLE; SEROTONIN; 5HT(2C) RECEPTOR; PARTIAL AGONIST; PSYCHIATRIC DISORDER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
M. Bos et al., "SYNTHESIS, PHARMACOLOGY AND THERAPEUTIC POTENTIAL OF 10-METHOXYPYRAZINO[1,2-A]INDOLES, PARTIAL AGONISTS AT THE 5HT(2C) RECEPTOR", European journal of medicinal chemistry, 32(3), 1997, pp. 253-261

Abstract

A series of new 10-methoxypyrazino[1,2-a]indoles has been prepared and shown to be 5HT(2C) receptor ligands. The studied compounds 10a-j were found to act as partial agonists at the 5HT(2C) receptor, binding with high affinity and moderate selectivity versus 5HT(1A) and 5HT(2A) receptors, but inducing only a submaximal increase in phosphoinositol formation. Compound 10j was demonstrated to be active in animal modelsof obsessive-compulsive disorder, depression and panic anxiety.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 12:23:50