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Titolo:
TRACER COUPLING AMONG REGENERATED AMACRINE CELLS IN THE RETINA OF THEGOLDFISH
Autore:
HITCHCOCK PF;
Indirizzi:
UNIV MICHIGAN,SCH MED,DEPT OPHTHALMOL,1000 WALL ST ANN ARBOR MI 48105 UNIV MICHIGAN,SCH MED,DEPT ANAT & CELL BIOL ANN ARBOR MI 48105
Titolo Testata:
Visual neuroscience
fascicolo: 3, volume: 14, anno: 1997,
pagine: 463 - 472
SICI:
0952-5238(1997)14:3<463:TCARAC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
INNER PLEXIFORM LAYER; CARP RETINA; GANGLION-CELLS; GAP-JUNCTIONS; MAMMALIAN RETINA; LUCIFER YELLOW; INJECTION; SYNAPSES; BIOCYTIN; GROWTH;
Keywords:
GAP JUNCTIONS; INTRACELLULAR INJECTIONS; BRAIN INJURY; NEURONAL REGENERATION; AMACRINE CELLS; TRACER COUPLING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
P.F. Hitchcock, "TRACER COUPLING AMONG REGENERATED AMACRINE CELLS IN THE RETINA OF THEGOLDFISH", Visual neuroscience, 14(3), 1997, pp. 463-472

Abstract

This study sought to characterize the tracer coupling of regenerated amacrine cells in the retina of the goldfish and assess the integration of regenerated neurons into existing retinal circuits. Regeneration of new neurons from injury-induced progenitors was stimulated by surgically excising a small rectangular piece of retina. Several months after regeneration was complete, intracellular injections of Neurobiotin,a gap junction-permeant tracer, were made into single regenerated amacrine cells or nonregenerated (extant) amacrine cells lying outside the regenerated patch. Two groups of amacrine cells were injected: thosethat in normal retina are tracer coupled and a single type (the radiate amacrine cell) that is not. The data show that regenerated amacrinecells are tracer coupled to each other and to their homologous counterparts outside the patch of regenerated retina. Regenerated radiate cells possess morphologically abnormal dendrites, but these processes can extend out of regenerated retina into surrounding normal retina. Similarly, the dendrites of extant radiate cells, severed by the originallesion, can regenerate into the patch of regenerated retina. These results indicate that in the goldfish retina the cell-specific junctional circuitry present in normal retina is re-created in the regenerated retina, and suggest that regenerated neurons are functionally integrated into the existing retina.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 21:43:14