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Titolo:
CHANGING TOPOGRAPHY OF THE RPE RESULTING FROM EXPERIMENTALLY-INDUCED RAPID EYE GROWTH
Autore:
FLEMING PA; HARMAN AM; BEAZLEY LD;
Indirizzi:
UNIV WESTERN AUSTRALIA,DEPT PSYCHOL NEDLANDS WA 6907 AUSTRALIA UNIV WESTERN AUSTRALIA,DEPT PSYCHOL NEDLANDS WA 6009 AUSTRALIA UNIV WESTERN AUSTRALIA,DEPT ZOOL NEDLANDS WA 6009 AUSTRALIA
Titolo Testata:
Visual neuroscience
fascicolo: 3, volume: 14, anno: 1997,
pagine: 449 - 461
SICI:
0952-5238(1997)14:3<449:CTOTRR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
RETINAL-PIGMENT EPITHELIUM; WALLABY SETONIX-BRACHYURUS; VISUAL DEPRIVATION MYOPIA; AREA CENTRALIS; TREE SHREWS; CLOSURE; CHICKS; QUOKKA; CELLS; ENLARGEMENT;
Keywords:
AGING; CELL SIZE; MAMMAL; MULTINUCLEATE; RETINAL GROWTH; DEVELOPMENT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Fleming et al., "CHANGING TOPOGRAPHY OF THE RPE RESULTING FROM EXPERIMENTALLY-INDUCED RAPID EYE GROWTH", Visual neuroscience, 14(3), 1997, pp. 449-461

Abstract

The retinal pigment epithelium (RPE) of the quokka wallaby, Setonix brachyurus, grows and changes throughout life. To investigate factors that determine changes in the quokka RPE, we have examined topography of this tissue in experimentally enlarged eyes. Unilateral eyelid suture was conducted at the time of normal eye opening, postnatal day (P) 110, and animals were examined at 1 or 1 1/2 years of age. The numbers and densities of RPE cells and the extent of multinucleation were compared with those in normal animals. Eyelid suture resulted in a 9.8% and 17.4% increase in retinal area at 1 and 1 1/2 years, respectively; asignificant degree of myopia was associated with this enlargement. Cell density topography in experimental eyes was not the same as in controls. Cells from central retina were disproportionately larger in the experimental than control eyes. However, the RPE cell topography in sutured eyes was not the same as that of aged retinae of a similar size. Notably, in sutured eyes there was no development of the high or highest cell densities seen in equatorial and temporal central RPE in agedretinae, respectively. Furthermore, the degree of cell enlargement inperipheral regions was slight compared with that observed in similar-sized, aged retinae. There was no increase in RPE cell number; rather,average cell area increased accompanied by no change or a slight decrease in RPE thickness. Consequently, overall volume of cells did not change significantly. The large number of multinucleate cells normally seen in aged animals was not observed in experimentally enlarged eyes,implying that an increase in cell volume may be the trigger for multinucleation.

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Documento generato il 24/09/20 alle ore 05:19:09