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Titolo:
FRONTAL-LOBE OF CHILDREN WITH SCHIZOPHRENIA SPECTRUM DISORDERS - A PROTON MAGNETIC-RESONANCE SPECTROSCOPIC STUDY
Autore:
BROOKS WM; HODDEVARGAS J; VARGAS LA; YEO RA; FORD CC; HENDREN RL;
Indirizzi:
UNIV NEW MEXICO,HLTH SCI CTR,CTR NONINVAS DIAG,1201 YALE B1 NE ALBUQUERQUE NM 87131 UNIV NEW MEXICO,CTR NONINVAS DIAG ALBUQUERQUE NM 87131 UNIV NEW MEXICO,DEPT NEUROSCI ALBUQUERQUE NM 87131 UNIV NEW MEXICO,DEPT CHILD PSYCHIAT ALBUQUERQUE NM 87131 UNIV NEW MEXICO,DEPT PSYCHOL ALBUQUERQUE NM 87131 UNIV NEW MEXICO,DEPT NEUROL ALBUQUERQUE NM 87131
Titolo Testata:
Biological psychiatry
fascicolo: 4, volume: 43, anno: 1998,
pagine: 263 - 269
SICI:
0006-3223(1998)43:4<263:FOCWSS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
MEMBRANE PHOSPHOLIPID-METABOLISM; SCHIZOTYPAL PERSONALITY-DISORDER; LONG-TERM STABILITY; PREFRONTAL CORTEX; IN-VIVO; ONSET SCHIZOPHRENIA; SYMPTOM DIMENSIONS; SYSTEMATIC SAMPLE; EARLY ADOLESCENCE; BRAIN MORPHOLOGY;
Keywords:
MAGNETIC RESONANCE SPECTROSCOPY; SCHIZOPHRENIA; CHILD; FRONTAL LOBE; NEUROCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
W.M. Brooks et al., "FRONTAL-LOBE OF CHILDREN WITH SCHIZOPHRENIA SPECTRUM DISORDERS - A PROTON MAGNETIC-RESONANCE SPECTROSCOPIC STUDY", Biological psychiatry, 43(4), 1998, pp. 263-269

Abstract

Background: Schizophrenia is commonly considered a neurodevelopmentaldisorder. Our aim was to determine whether the proton magnetic resonance spectroscopic (H-1-MRS) changes seen in adults with schizophrenia are displayed in children at risk for developing schizophrenia. Methods: Children with symptoms of schizophrenia-spectrum disorders (n = 16;mean age = 132 months) and a comparison group (n = 22; mean age 130 months) took part in a H-1-MRS study of the left frontal lobe. Areas ofpeaks from N-acetylaspartate (NAA), choline (Cho), and creatine (Cre)were determined and ratios of NAA/Cre and Cho/Cre calculated and compared between groups. Results: The mean ratio of NAA/Cre was significantly lower in schizophrenia-spectrum subjects than the comparison group(1.67 vs. 1.92; p < .05). Medication status did not affect results inschizophrenia-spectrum subjects. Conclusions: Our findings suggest that the metabolic changes associated with adult schizophrenia are observed in children with some or all of the symptoms of schizophrenia, supporting a neurodevelopmental theory for schizophrenia. (C) 1998 Society of Biological Psychiatry.

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Documento generato il 02/04/20 alle ore 22:24:11