Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
APOLIPOPROTEIN-E - DEPRESSIVE-ILLNESS, DEPRESSIVE SYMPTOMS, AND ALZHEIMERS-DISEASE
Autore:
HOLMES C; RUSS C; KIROV G; AITCHISON KJ; POWELL JF; COLLIER DA; LOVESTONE S;
Indirizzi:
INST PSYCHIAT,OLD AGE PSYCHIAT SECT,DE CRESPIGNY PK,DENMARK HILL LONDON SE5 8AF ENGLAND INST PSYCHIAT,DEPT NEUROSCI LONDON SE5 8AF ENGLAND INST PSYCHIAT,DEPT PSYCHOL MED LONDON SE5 8AF ENGLAND
Titolo Testata:
Biological psychiatry
fascicolo: 3, volume: 43, anno: 1998,
pagine: 159 - 164
SICI:
0006-3223(1998)43:3<159:A-DDSA>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LATE-LIFE DEPRESSION; GERIATRIC DEPRESSION; AFFECTIVE-DISORDER; FAMILY HISTORY; DEMENTIA; ASSOCIATION; ALLELE; FREQUENCY; SCALE; MOOD;
Keywords:
APOLIPOPROTEIN E; DEPRESSIVE ILLNESS; ALZHEIMERS DISEASE; DEPRESSIVE SYMPTOMS; PSYCHOPATHOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
C. Holmes et al., "APOLIPOPROTEIN-E - DEPRESSIVE-ILLNESS, DEPRESSIVE SYMPTOMS, AND ALZHEIMERS-DISEASE", Biological psychiatry, 43(3), 1998, pp. 159-164

Abstract

Background: The apolipoprotein E (ApoE) epsilon 4 and epsilon 2 alleles may influence the age of onset of depressive illness. Depressive illness of late onset is also a risk factor for Alzheimer's disease (AD), and there is some evidence that the ApoE epsilon 2 allele is associated with depressive symptomatology in AD, Depressive symptomatology inAD may thus share common genetic risk factors with late-onset depressive illness. Methods: The frequency of the epsilon 2 and epsilon 4 alleles of ApoE and their effects on age of onset of disease in three independent groups of subjects, with depressive illness, with AD, and controls, were compared in a defined population from Southeast London. Results: The frequency of the ApoE epsilon 2 allele was significantly lower in the depressive illness group compared with the control group and was associated with a later mean age at onset. Subjects with depressive symptomatology in AD had a higher frequency of the ApoE epsilon 2 allele and had a significantly later age of onset of depressive illness compared with the nondepressed AD group. Conclusions: The presence of the ApoE epsilon 2 allele in AD is found to be highly associated with depressive symptomatology, and it is proposed that this subgroup represents the presence of delayed depressive illness and that there are common genetic risk factors between AD and depressive illness. (C) 1998 Society of Biological Psychiatry.

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Documento generato il 05/04/20 alle ore 23:04:22