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Titolo:
SELECTIVE SENSITIZATION TO THE PSYCHOSIS-INDUCING EFFECTS OF COCAINE - A POSSIBLE MARKER FOR ADDICTION RELAPSE VULNERABILITY
Autore:
BARTLETT E; HALLIN A; CHAPMAN B; ANGRIST B;
Indirizzi:
VET ADM MED CTR,PSYCHIAT SERV,116A,423 E 23RD ST NEW YORK NY 10010 VET ADM MED CTR,PSYCHIAT SERV NEW YORK NY 10010 NYU,SCH MED,DEPT PSYCHIAT NEW YORK NY 00000
Titolo Testata:
Neuropsychopharmacology
fascicolo: 1, volume: 16, anno: 1997,
pagine: 77 - 82
SICI:
0893-133X(1997)16:1<77:SSTTPE>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED PARANOIA;
Keywords:
COCAINE; PSYCHOSIS; SENSITIZATION; ADDICTION; RELAPSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
E. Bartlett et al., "SELECTIVE SENSITIZATION TO THE PSYCHOSIS-INDUCING EFFECTS OF COCAINE - A POSSIBLE MARKER FOR ADDICTION RELAPSE VULNERABILITY", Neuropsychopharmacology, 16(1), 1997, pp. 77-82

Abstract

Patients in inpatient rehabilitation for uncomplicated cocaine dependence were asked whether, compared with the time of their first regularuse, they could now identify changes in the effects of similar doses of cocaine. We asked about a spectrum of cocaine effects ''then'' and ''now'' and whether the same amount of drug caused effects to occur toabout the same degree, less intensely (tolerance), or more intensely (sensitization). Nearly half our sample developed predominantly paranoid psychoses in the context of cocaine use. Sensitization was consistently linked only to psychosis-related cocaine effects. It hits been proposed that mesolimbic dopaminergic sensitization might contribute to addiction severity. A preliminary followup of patients who were sensitized or nonsensitized to psychosis development suggests that rehospitalization for treatment of addiction may be more frequent in the sensitized group. (C) 1997 American Institute of Neuropsychopharmacology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 19:07:20