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Titolo:
NEUROLOGICAL SYNDROMES OF ORGANOPHOSPHORUS COMPOUNDS
Autore:
JAMAL GA;
Indirizzi:
SO GEN HOSP,INST NEUROL SCI,NHS TRUST,DEPT NEUROL GLASGOW G51 4TF LANARK SCOTLAND
Titolo Testata:
Adverse drug reactions and toxicological reviews
fascicolo: 3, volume: 16, anno: 1997,
pagine: 133 - 170
SICI:
0964-198X(1997)16:3<133:NSOOC>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPATHY TARGET ESTERASE; INDUCED DELAYED NEUROTOXICITY; IMPROVED AUTOMATED-METHOD; ORGANO-PHOSPHORUS ESTERS; CENTRAL-NERVOUS-SYSTEM; PHENYLMETHANESULFONYL FLUORIDE; CHOLINESTERASE INHIBITION; PESTICIDE APPLICATORS; AXONAL DEGENERATION; TOXIC NEUROPATHIES;
Keywords:
ORGANOPHOSPHATES; INSECTICIDES; NEUROLOGICAL; NEUROBEHAVIORAL; NEUROTOXICITY; PSYCHIATRIC; ELECTROENCEPHALOGRAPHY; ELECTROMYOGRAPHY; SINGLE FIBER EMG; JITTER; NERVE CONDUCTION; NEUROPHYSIOLOGY; QUANTITATIVE SENSORY TESTS; AUTONOMIC NERVOUS SYSTEM; EVOKED POTENTIALS; NEUROMUSCULAR JUNCTION; COGNITIVE DYSFUNCTION; NEUROPATHY;
Tipo documento:
Review
Natura:
Periodico
Citazioni:
163
Recensione:
Indirizzi per estratti:
Citazione:
G.A. Jamal, "NEUROLOGICAL SYNDROMES OF ORGANOPHOSPHORUS COMPOUNDS", Adverse drug reactions and toxicological reviews, 16(3), 1997, pp. 133-170

Abstract

In addition to the acute cholinergic poisoning, organophosphorus (OF)compounds are capable of producing several subacute, delayed and chronic neurological, neurobehavioural and psychiatric syndromes. These include the intermediate syndrome, the organophosphate induced delayed neuropathy (OPIDN) and a number of chronic neurological and psychiatricmanifestations lumped in this review under the term chronic organophosphate induced neuropsychiatric disorder (COPIND). A critical review of the concept of the neuropathy target esterase (NTE) inhibition and ageing as a marker of OPIDN and the related hen test is presented. It is concluded that the use of the hen test as an exclusive screening test for neurotoxicity of organophosphorus compounds is flawed. A number of recent studies are presented to demonstrate the unreliability of the test and flaws of scientific concepts underlying the hen test which is used to identify OPs as safe and ''non-neurotoxic''. The componentsof this new COPIND syndrome are described and the evidence for its existence is reviewed. Studies are in progress to further determine the profile of this syndrome and to define the overlap between its variouscomponents. The review also attempts to determine the clinical features so far described of these components and the investigations or markers used to identify and characterize COPIND and the behaviour of these markers. Evidence for chronic neurological/psychiatric effects of OPcompounds have come from case studies, clusters of neurological diseases or from epidemiological investigations. New concepts in neurotoxicology are being produced from recent studies which may necessitate a new radical approach to the assessment of neurotoxicity of pesticides before releasing them for widespread use.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 17:45:01