Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ALTERED MYOCARDIAL VASODILATATION IN PATIENTS WITH HYPERTRIGLYCERIDEMIA IN ANATOMICALLY NORMAL CORONARY-ARTERIES
Autore:
YOKOYAMA I; OHTAKE T; MOMOMURA S; YONEKURA K; KOBAYAKAWA N; AOYAGI T; SUGIURA S; SASAKI Y; OMATA M;
Indirizzi:
UNIV TOKYO,DEPT INTERNAL MED 2,BUNKYO KU,7-3-1 HONGO TOKYO 113 JAPAN UNIV TOKYO,DEPT RADIOL,BUNKYO KU TOKYO 113 JAPAN
Titolo Testata:
Arteriosclerosis, thrombosis, and vascular biology
fascicolo: 2, volume: 18, anno: 1998,
pagine: 294 - 299
SICI:
1079-5642(1998)18:2<294:AMVIPW>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BLOOD-FLOW; N-13 AMMONIA; HYPERCHOLESTEROLEMIC PATIENTS; ENDOTHELIAL DYSFUNCTION; PLASMA TRIGLYCERIDES; INSULIN RESISTANCE; NITRIC-OXIDE; RESERVE; QUANTIFICATION;
Keywords:
HYPERLIPIDEMIA; HYPERTRIGLYCERIDEMIA; ATHEROSCLEROSIS; MYOCARDIAL VASODILATATION; PET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
I. Yokoyama et al., "ALTERED MYOCARDIAL VASODILATATION IN PATIENTS WITH HYPERTRIGLYCERIDEMIA IN ANATOMICALLY NORMAL CORONARY-ARTERIES", Arteriosclerosis, thrombosis, and vascular biology, 18(2), 1998, pp. 294-299

Abstract

Reduced myocardial vasodilatation (MVD) in hypercholesterolemics without overt coronary stenosis has been reported. However, the status of MVD in hypertriglyceridemics has not yet been clarified. The aim of this study was to investigate whether MVD is impaired in patients with hypertriglyceridemia without overt coronary stenosis, Twenty-three hypertriglyceridemics (10 normocholesterolemic hypertriglyceridemics [HTGs] and lj mixed combined hyperlipidemics [MCHLs]) and 13 age-matched controls were studied. All patients were proven to have more than one normal coronary artery, as diagnosed by coronary angiography, and those segments that were perfused by anatomically normal coronary arteries were used in the study. Myocardial blood now (MBF) during dipyridamole DP) loading and baseline MBF were measured by using positron emission tomography and [N-13]]ammonia, after which MVD was calculated. Baseline MBF (mt min(-1) 100 g(-1)) was comparable among HTG (76.0+/-26.1), MCHL (77.0+/-26.1), and controls (80.3+/-38.5). However, MBF during DP loading was significantly lower in MCHL (159+/-52.5) than in control subjects (292+/-166, P<.01), while it was comparable in HTG (202+/-104)and controls. MVD was significantly reduced in both HTG (2.70+/-1.09,P<.05) and MCHL (2.07+/-.70, P<.01) compared with controls (3.73+/-1.14). MVD in MCHLs tended to be reduced compared with that in HTGs, butthe difference was statistically insignificant (P=.08). There was a significant relationship between MVD and both plasma triglycerides (r=-.47, P<.01) and plasma total cholesterol (r=-.55 P<.01). When controlsand HTGs were combined, the relationship between MVD and plasma totaltriglycerides became more prominent (r=-.55, PV.05), and the significant relationship between cholesterol level and MVD disappeared. Multivariate regression analysis has revealed that the triglyceride level (F=5.2, P<0.5) was independently related to MVD (r=.69, P<.05). In conclusion, MVD was reduced in hypertriglyceridemics in anatomically normalcoronary arteries. Hypertriglyceridemia is an independent factor for this abnormality.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 09:22:16