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Titolo:
DEXTERITY IN ADULT MONKEYS FOLLOWING EARLY LESION OF THE MOTOR CORTICAL HAND AREA - THE ROLE OF CORTEX ADJACENT TO THE LESION
Autore:
ROUILLER EM; YU XH; MORET V; TEMPINI A; WIESENDANGER M; LIANG F;
Indirizzi:
UNIV FRIBOURG,INST PHYSIOL,FAC SCI,RUE MUSEE 5 CH-1700 FRIBOURG SWITZERLAND
Titolo Testata:
European journal of neuroscience
fascicolo: 2, volume: 10, anno: 1998,
pagine: 729 - 740
SICI:
0953-816X(1998)10:2<729:DIAMFE>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
SENSORIMOTOR CORTEX; FUNCTIONAL RECOVERY; MACAQUE MONKEY; CORTICOSPINAL PROJECTIONS; SOMATOTOPIC ORGANIZATION; MOVEMENT REPRESENTATIONS; BRAIN INFARCTION; SQUIRREL-MONKEYS; RHESUS-MONKEY; NERVE INJURY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
E.M. Rouiller et al., "DEXTERITY IN ADULT MONKEYS FOLLOWING EARLY LESION OF THE MOTOR CORTICAL HAND AREA - THE ROLE OF CORTEX ADJACENT TO THE LESION", European journal of neuroscience, 10(2), 1998, pp. 729-740

Abstract

Infant monkeys were subjected to unilateral lesions of the motor cortex (mainly its hand representation). After maturation, they showed normal use of the contralateral hand for global grip movements. However, as compared with the ipsilateral hand, precision grip tasks requiring relatively independent finger movements were performed with less dexterity, particularly if adjustments of the wrist position were necessary. The purpose of this study was to investigate mechanisms which may beresponsible for the rather well, although not complete, preservation of manipulative behaviour of these adult monkeys. To this end, the hand representations were mapped bilaterally with intracortical microstimulation in the mature monkeys, and the dexterity of both hands assessed quantitatively in a precision grip task. The behavioural effects of reversible inactivations of the primary (Mi) and supplementary (SMA) motor cortical areas were then tested. The following were found. (i) The hand contralateral to the lesion exhibited subtle but significant dexterity deficits, as compared with the ipsilateral hand; the deficit was essentially for complex movements requiring dissociation of the thumb-index finger pinch from the other digits, involving also an arm rotation. (ii) Reversible inactivation of the M1 hand representation in the intact hemisphere dramatically impaired dexterity of the opposite hand without affecting the ipsilateral hand (contralateral to the earlylesion). (iii) A relatively complete hand representation was found tooccupy a new territory, medial to the old lesion. (iv) The role of this new displaced representation was crucial for the preserved dexterity of the opposite hand, as evidenced by its functional inactivation. In contrast, inactivation of both SMA cortices did not interfere with the manipulative behaviour. it is thus concluded that the preserved functional capacity of manipulations with the hand opposite the early lesion can be essentially attributed to a cortical reorganization around the old lesion. Under the present experimental conditions, contributions from either the SMA or the intact M1 appear not to be crucial.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 04:25:32