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Titolo:
UNCOUPLING PROTEIN-3 - A MUSCLE-SPECIFIC GENE UP-REGULATED BY LEPTIN IN OB OB MICE/
Autore:
LIU QY; BAI C; CHEN F; WANG RP; MACDONALD T; GU MC; ZHANG Q; MORSY MA; CASKEY CT;
Indirizzi:
MERCK SHARP & DOHME LTD,RES LABS,DEPT HUMAN GENET,WP26A-3000 W POINT PA 19486
Titolo Testata:
Gene
fascicolo: 1, volume: 207, anno: 1998,
pagine: 1 - 7
SICI:
0378-1119(1998)207:1<1:UP-AMG>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEOTIDE-BINDING-SITE; BROWN ADIPOSE-TISSUE; FATTY-ACIDS; MITOCHONDRIA; TRANSPORT; OBESITY; LEAK;
Keywords:
SKELETAL MUSCLE; MITOCHONDRIA; OBESITY; THERMOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
Q.Y. Liu et al., "UNCOUPLING PROTEIN-3 - A MUSCLE-SPECIFIC GENE UP-REGULATED BY LEPTIN IN OB OB MICE/", Gene, 207(1), 1998, pp. 1-7

Abstract

We identified and partially characterized another member of the uncoupling protein termed UCP3. Human and mouse UCP3 protein sequences are 86% identical to each other, and 73% and 59% identical to UCP2 and UCP1, respectively. Expression of human UCP3 in yeast resulted in a drastic decrease of mitochondria membrane potential. Northern analysis showed that UCP3 was highly expressed in skeletal muscle in human, rat, and mouse. Mapping of UCP3 placed it to the same chromosomal region of UCP2 in both human and mouse, a region that is linked to obesity and hyperinsulinemia. Furthermore, adenovirus-mediated leptin expression in obese ob/ob mice led to increased expression of UCP3 in skeletal muscle. The data indicate that UCP3 encodes a muscle-specific uncoupling protein that may play an important role in the regulation of energy expenditure and development of obesity. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 11:25:40