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Titolo:
ACYCLOVIR-RESISTANT ZOSTER IN AN IMMUNOCO MPROMISED HIV SERONEGATIVE PATIENT
Autore:
LESUEUR A; FILLET AM; BOUSCARY D; GINSBURG C; PALMER P; CHAINE B; SALMONCERON D; DREYFUS F; HURAUX JM; SICARD D;
Indirizzi:
HOP COCHIN,SERV MED INTERNE 2,27 RUE FAUBOURG ST JACQUES F-75014 PARIS FRANCE HOP LA PITIE SALPETRIERE,CERVI,SERV VIROL F-75651 PARIS 13 FRANCE HOP COCHIN,SERV HEMATOL F-75014 PARIS FRANCE HOP ST VINCENT DE PAUL,VIROL LAB F-75014 PARIS FRANCE
Titolo Testata:
Annales de dermatologie et de venereologie
fascicolo: 2, volume: 125, anno: 1998,
pagine: 127 - 128
SICI:
0151-9638(1998)125:2<127:AZIAIM>2.0.ZU;2-7
Fonte:
ISI
Lingua:
FRE
Soggetto:
VIRUS-INFECTION; HERPES-SIMPLEX; AIDS; THERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
A. Lesueur et al., "ACYCLOVIR-RESISTANT ZOSTER IN AN IMMUNOCO MPROMISED HIV SERONEGATIVE PATIENT", Annales de dermatologie et de venereologie, 125(2), 1998, pp. 127-128

Abstract

Introduction. Resistance to antiviral therapy is getting actually more frequent. Immunocompromised host are more concerned with this problem. Observation. We present a case of disseminated tester resisting to acyclovir (ACV) therapy, but healing with foscarnet in a man treated with chemotherapy for lymphoma and seronegative for HIV. CI50 of VZV strain was 48 mu M for ACV, which was 2,8 times higher than value of thereference OKA strain tested simultaneously, which confirmed the resistance for ACV. Discussion. Immunocompromised patients often present varicella tester virus (VZV) infection. They usually heal in response toACV therapy, but some HIV infected patients have already presented with resistant strains of VZV. This case is the first described in a non-HIV infected patient. Foscarnet therapy resulted twice in compleate healing because of its direct activity on viral DNA polymerase, so it is. efficaceous therapy for patients with thymidine-kinase-deficient ACV-resistant VZV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 00:44:14