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Titolo:
HEMATOPOIETIC GROWTH-FACTORS ARE DIFFERENTIALLY REGULATED IN MONOCYTES AND CD4(-LYMPHOCYTES - INFLUENCE OF IFN-ALPHA AND INTERLEUKIN-4() T)
Autore:
TRETTER T; AMAN MJ; BUG G; HUBER C; PESCHEL C;
Indirizzi:
TECH UNIV MUNICH,DEPT INTERNAL MED 3,ISMANINGERSTR 22 D-81664 MUNICH GERMANY UNIV MAINZ,SCH MED,DEPT MED 3 D-6500 MAINZ GERMANY TECH UNIV MUNICH,DEPT MED 3 D-8000 MUNICH GERMANY
Titolo Testata:
Journal of interferon & cytokine research
fascicolo: 2, volume: 18, anno: 1998,
pagine: 95 - 102
SICI:
1079-9907(1998)18:2<95:HGADRI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
COLONY-STIMULATING FACTOR; NECROSIS-FACTOR-ALPHA; BLOOD MONONUCLEAR-CELLS; MARROW STROMAL CELLS; HUMAN POLYMORPHONUCLEAR NEUTROPHILS; GRANULOCYTE-MACROPHAGE-CSF; FACTOR GENE-EXPRESSION; FACTOR GM-CSF; MHC CLASS-II; INTERFERON-ALPHA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
T. Tretter et al., "HEMATOPOIETIC GROWTH-FACTORS ARE DIFFERENTIALLY REGULATED IN MONOCYTES AND CD4(-LYMPHOCYTES - INFLUENCE OF IFN-ALPHA AND INTERLEUKIN-4() T)", Journal of interferon & cytokine research, 18(2), 1998, pp. 95-102

Abstract

We investigated the influence of interferon-alpha (IFN-alpha) on the synthesis of granulocyte-macrophage colony-stimulating factor (GM-CSF)and interleukin-3 (IL-3) by monocytes and activated T helper cells, IFN-alpha inhibited the production of GM-CSF in unstimulated and lipopolysaccharide (LPS)-activated monocytes to the same extent as was observed in the presence of IL-4, In highly purified CD4(+) T cells, which were activated by incubation with immobilized anti-CD3 antibody and anti-CD28, IFN-alpha reduced production of GM-CSF to 47%. In contrast, GM-CSF production in activated T cells was unaffected by exogenously added IL-4. The production of IL-3 by T helper cells was significantly inhibited by IFN-alpha as well, IL-3 production by CD3/CD28-stimulated T helper cells was exclusively enhanced by IL-4, The exogenous addition of IL-4 led to a highly significant increase of IL-3 levels in T cell supernatants to 231% of control cultures (range 137%-605%), whereas other T cell-derived cytokines, such as IFN-gamma and IL-10, failed toinfluence IL-3 release, The differential role of IL-4 in IL-3 production was confirmed by the addition of anti-IL-4 antibodies to CD3/CD28-stimulated T cells, Neutralizing anti-IL-4 antibody caused a drastic reduction of IL-3 synthesis by activated T cells, whereas GM-CSF production was independent of neutralization-of endogenous IL-4, These experiments define IFN-alpha as an inhibitory substance for the production of hematopoietic growth factors by activated immune cells. The influence of IL-4 on cytokine synthesis appears to be cell type specific, thus revealing a differential stimulatory effect on IL-3 production.

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Documento generato il 04/07/20 alle ore 18:26:49