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Titolo:
THE DUG GENE OF DROSOPHILA-MELANOGASTER ENCODES A STRUCTURAL AND FUNCTIONAL HOMOLOG OF THE SACCHAROMYCES-CEREVISIAE SUG1 PREDICTED ATPASE ASSOCIATED WITH THE 26S PROTEASOME
Autore:
MOUNKES LC; FULLER MT;
Indirizzi:
STANFORD UNIV,SCH MED,BECKMAN CTR,DEPT DEV BIOL,B300 STANFORD CA 94305 STANFORD UNIV,SCH MED,BECKMAN CTR,DEPT DEV BIOL STANFORD CA 94305 STANFORD UNIV,SCH MED,BECKMAN CTR,DEPT GENET STANFORD CA 94305
Titolo Testata:
Gene
fascicolo: 2, volume: 206, anno: 1998,
pagine: 165 - 174
SICI:
0378-1119(1998)206:2<165:TDGODE>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
TAT-BINDING PROTEIN; NF-KAPPA-B; RNA-POLYMERASE-II; MEDIATED TRANSACTIVATION; SACCHAROMYCES-CEREVISIAE; PEROXISOME BIOGENESIS; POSITIVE MODULATOR; PUTATIVE ATPASES; 26-S PROTEASE; YEAST;
Keywords:
DUG; DROSOPHILA; PROTEASOME; YEAST SUG1; CAD PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
L.C. Mounkes e M.T. Fuller, "THE DUG GENE OF DROSOPHILA-MELANOGASTER ENCODES A STRUCTURAL AND FUNCTIONAL HOMOLOG OF THE SACCHAROMYCES-CEREVISIAE SUG1 PREDICTED ATPASE ASSOCIATED WITH THE 26S PROTEASOME", Gene, 206(2), 1998, pp. 165-174

Abstract

The DUG gene of Drosophila encodes a putative ATPase that is a structural and functional homolog of the yeast SUG1 product. When introducedinto S. cerevisiae, the Drosophila DUG gene rescued the lethality associated with a SUGI mutant. Anti-DUG antibodies recognized a protein that migrated in high molecular weight complexes, along with componentsof the 26S proteasome, and also immunoprecipitated components of the 26S proteasome from embryonic extracts. Proteins recognized by the affinity-purified antibody raised against DUG were localized in either a punctate cytoplasmic distribution or in the nucleus, depending on the cell type, consistent with the subcellular localization of the 26S proteasome in various cell types. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/08/20 alle ore 02:44:26