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Titolo:
INTERACTION OF THE HIV-1 REV COFACTOR EUKARYOTIC INITIATION-FACTOR 5AWITH RIBOSOMAL-PROTEIN L5
Autore:
SCHATZ O; OFT M; DASCHER C; SCHEBESTA M; ROSORIUS O; JAKSCHE H; DOBROVNIK M; BEVEC D; HAUBER J;
Indirizzi:
UNIV ERLANGEN NURNBERG,INST CLIN & MOL VIROL,SCHLOSSGARTEN 4 D-91054 ERLANGEN GERMANY UNIV ERLANGEN NURNBERG,INST CLIN & MOL VIROL D-91054 ERLANGEN GERMANY NOVARTIS RES INST A-1235 VIENNA AUSTRIA RES INST MOL PATHOL A-1030 VIENNA AUSTRIA MED POLICLIN D-80336 MUNICH GERMANY
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 4, volume: 95, anno: 1998,
pagine: 1607 - 1612
SICI:
0027-8424(1998)95:4<1607:IOTHRC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; NUCLEAR EXPORT SIGNAL; VIRAL MESSENGER-RNA; GENE-EXPRESSION REQUIRES; ACTIVATION DOMAIN; TRANS-ACTIVATOR; NUCLEOCYTOPLASMIC TRANSPORT; NUCLEOLAR LOCALIZATION; TARGET SEQUENCE; HNRNP A1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
64
Recensione:
Indirizzi per estratti:
Citazione:
O. Schatz et al., "INTERACTION OF THE HIV-1 REV COFACTOR EUKARYOTIC INITIATION-FACTOR 5AWITH RIBOSOMAL-PROTEIN L5", Proceedings of the National Academy of Sciences of the United Statesof America, 95(4), 1998, pp. 1607-1612

Abstract

It has previously been shown that interaction of eukaryotic initiation factor 5A (eIF-SA) with the Rev trans-activator protein of HIV-1 mediates the transport of unspliced or incompletely spliced viral mRNAs across the nuclear envelope, Consequently, mutants of eIF-SA block Rev function and thereby replication of HIV-1 in trans, indicating that eIF-SA is a crucial protein that connects the viral Rev regulator with cellular RNA transport systems, Here we show that the ribosomal proteinL5, which is the central protein component of the 5S rRNA export system, is a cellular interaction partner of eIF-SA, Functional studies demonstrate that overexpression of L5 protein significantly enhances Revactivity, Furthermore, Rev nuclear export activity is inhibited in human somatic cells by antibodies that recognize eIF-SA or L5, Our data suggest that the Rev export pathway shares components of a cellular transport system involved in the intracellular trafficking of polymeraseIII (5S rRNA) transcripts.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 05:25:48