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Titolo:
OPIUM ALKALOID NOSCAPINE IS AN ANTITUMOR AGENT THAT ARRESTS METAPHASEAND INDUCES APOPTOSIS IN DIVIDING CELLS
Autore:
YE KQ; KE Y; KESHAVA N; SHANKS J; KAPP JA; TEKMAL RR; PETROS J; JOSHI HC;
Indirizzi:
EMORY UNIV,SCH MED,GRAD PROGRAM BIOCHEM & MOL BIOL ATLANTA GA 30322 EMORY UNIV,SCH MED,GRAD PROGRAM BIOCHEM & MOL BIOL ATLANTA GA 30322 EMORY UNIV,SCH MED,DEPT ANAT & CELL BIOL ATLANTA GA 30322 EMORY UNIV,SCH MED,DEPT PATHOL ATLANTA GA 30322 EMORY UNIV,SCH MED,DEPT OBSTET GYNECOL ATLANTA GA 30322 EMORY UNIV,SCH MED,DEPT UROL ATLANTA GA 30322
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 4, volume: 95, anno: 1998,
pagine: 1601 - 1606
SICI:
0027-8424(1998)95:4<1601:OANIAA>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
MICROTUBULE ASSEMBLY INVITRO; BINDING-SITES; H-3 NOSCAPINE; BRAIN; TAXOL; PHARMACOKINETICS; HYDROCHLORIDE; CHECKPOINTS; POLYPLOIDY; MECHANISM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
K.Q. Ye et al., "OPIUM ALKALOID NOSCAPINE IS AN ANTITUMOR AGENT THAT ARRESTS METAPHASEAND INDUCES APOPTOSIS IN DIVIDING CELLS", Proceedings of the National Academy of Sciences of the United Statesof America, 95(4), 1998, pp. 1601-1606

Abstract

An alkaloid from opium, noscapine, is used as an antitussive drug andhas low toxicity in humans and mice. We show that noscapine binds stoichiometrically to tubulin, alters its conformation, affects microtubule assembly, and arrests mammalian cells in mitosis. Furthermore, noscapine causes apoptosis in many cell types and has potent antitumor activity against solid murine lymphoid tumors (even when the drug was administered orally) and against human breast and bladder tumors implanted in nude mice. Because noscapine is water-soluble and absorbed after oral administration, its chemotherapeutic potential in human cancer merits thorough evaluation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/07/20 alle ore 22:29:25