Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INHALED NITRIC-OXIDE NEITHER ALTERS OXIDATIVE STRESS PARAMETERS NOR INDUCES LUNG INFLAMMATION IN PREMATURE LAMBS WITH MODERATE HYALINE-MEMBRANE DISEASE
Autore:
STORME L; ZERIMECH F; RIOU Y; MARTINPONTHIEU A; DEVISME L; SLOMIANNY C; KLOSOWSKI S; DEWAILLY E; CNEUDE F; ZANDECKI M; DUPUIS B; LEQUIEN P;
Indirizzi:
CTR HOSP REG & UNIV LILLE,SERV MED NEONATALE,HOP JEANNE DE FLANDRE,DEPT NEONATOL,PL VERDUN F-59037 LILLE FRANCE CTR HOSP REG & UNIV LILLE,SERV MED NEONATALE,HOP JEANNE DE FLANDRE,DEPT NEONATOL F-59037 LILLE FRANCE CHRU,DEPT BIOCHEM LILLE FRANCE CHRU,DEPT PATHOL LILLE FRANCE CHRU,DEPT HEMATOL LILLE FRANCE CHRU,INSERM,U42 LILLE FRANCE CHRU,DEPT EXPT PHARMACOL LILLE FRANCE
Titolo Testata:
Biology of the neonate
fascicolo: 3, volume: 73, anno: 1998,
pagine: 172 - 181
SICI:
0006-3126(1998)73:3<172:INNAOS>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION; ANTIOXIDANT STATUS; NITROGEN-DIOXIDE; PEROXYNITRITE; CYTOTOXICITY; RESISTANCE; INHALATION; TOXICITY; KINETICS;
Keywords:
INHALED NITRIC OXIDE; OXIDATIVE STRESS; ACUTE LUNG INJURY; HYALINE MEMBRANE DISEASE; PREMATURE LAMBS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
L. Storme et al., "INHALED NITRIC-OXIDE NEITHER ALTERS OXIDATIVE STRESS PARAMETERS NOR INDUCES LUNG INFLAMMATION IN PREMATURE LAMBS WITH MODERATE HYALINE-MEMBRANE DISEASE", Biology of the neonate, 73(3), 1998, pp. 172-181

Abstract

The purpose of this investigation was to examine whether inhaled nitric oxide (NO) map alter oxidative stress parameters and induce lung inflammation in moderate hyaline membrane disease (HMD). Eighteen moderately premature lambs (130 days gestation, term = 147 days) were randomly assigned to treatment with 20 ppm inhaled NO (n = 8) from the onsetof ventilation or used as control (n = 10). Except inhaled NO, treatments were intentionally similar to those applied in clinical situations. The main studied parameters were oxidative stress index measurements on lung parenchyma and in circulating blood, lung parenchyma microscopic examination and bronchoalveolar lavage cell count. We found that 20 ppm of inhaled NO for 5 h did not change significantly either malondialdehyde and total antioxidant status levels in circulating blood, or malondialdehyde, reduced glutathione, glutathione peroxidase and glutathione reductase in lung parenchyma. Amino-imino-propene bond generation, which are lipoperoxidation markers, was similar in both groups. Furthermore, no significant changes in the number of inflammatory cells in lung lavage products and in lung parenchyma microscopic examination could be found. Therefore, these data do not support the hypothesisthat short-term NO inhalation increases oxidative stress and lung inflammation in an experimental model of moderate HMD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:43:29