Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
PRESYNAPTIC NICOTINIC RECEPTORS FACILITATE MONOAMINERGIC TRANSMISSION
Autore:
LI XY; RAINNIE DG; MCCARLEY RW; GREENE RW;
Indirizzi:
VET ADM MED CTR,NEUROSCI LAB 151C,940 BELMONT ST BROCKTON MA 02401 VET ADM MED CTR,NEUROSCI LAB 151C BROCKTON MA 02401 HARVARD UNIV,SCH MED BROCKTON MA 02401
Titolo Testata:
The Journal of neuroscience
fascicolo: 5, volume: 18, anno: 1998,
pagine: 1904 - 1912
SICI:
0270-6474(1998)18:5<1904:PNRFMT>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE NEURONS; ANTIDEPRESSANT BINDING-SITES; SYNAPTIC TRANSMISSION; HIPPOCAMPAL-NEURONS; H-3 PAROXETINE; SLEEP CYCLE; HUMAN-BRAIN; RAT; SEROTONIN; INVITRO;
Keywords:
NOREPINEPHRINE; SEROTONIN; ACETYLCHOLINE; METHYLLYCACONITINE; DORSAL RAPHE; ELECTROPHYSIOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
46
Recensione:
Indirizzi per estratti:
Citazione:
X.Y. Li et al., "PRESYNAPTIC NICOTINIC RECEPTORS FACILITATE MONOAMINERGIC TRANSMISSION", The Journal of neuroscience, 18(5), 1998, pp. 1904-1912

Abstract

Nicotine is reported to increase arousal and attention and to elevatemood, effects that are most often associated with changes in the function of monoaminergic neuromodulatory systems (Feldman et al., 1997). Recent studies have shown a nicotinic receptor-mediated presynaptic enhancement of fast glutamatergic (McGehee et al., 1995; Gray et al., 1996) and GABAergic (Lena and Changeux, 1997) transmission. However, themechanism of nicotinic effects on metabotropic-mediated transmission in general, and on monoaminergic transmission in particular, is less well understood. We have examined nicotinic effects on dorsal raphe neurons of rats using whole-cell current and voltage-clamp recording techniques in vitro. In the majority of these neurons, activation of presynaptic nicotinic receptors induced a depolarization mediated by norepinephrine acting on alpha 1 receptors. Blockade of this response revealed a hyperpolarization mediated by serotonin acting on 5-HT1A receptors. Because the norepinephrine effect was sensitive to methyllycaconitine (100 nM), it is concluded that nicotinic receptors with an alpha 7 subunit can facilitate release of norepinephrine to activate metabotropic receptors. In contrast, methyllycaconitine-insensitive nicotinic receptors can induce 5-HT release in the dorsal raphe nucleus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/04/20 alle ore 00:31:20