Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
ACTIVATION OF SEROTONERGIC NEURONS IN THE RAPHE MAGNUS IS NOT NECESSARY FOR MORPHINE ANALGESIA
Autore:
GAO KM; CHEN DO; GENZEN JR; MASON P;
Indirizzi:
UNIV CHICAGO,DEPT PHARMACOL & PHYSIOL SCI,947 E 58TH ST,MC 0926 CHICAGO IL 60637 UNIV CHICAGO,DEPT PHARMACOL & PHYSIOL SCI CHICAGO IL 60637 UNIV CHICAGO,COMM NEUROBIOL CHICAGO IL 60637
Titolo Testata:
The Journal of neuroscience
fascicolo: 5, volume: 18, anno: 1998,
pagine: 1860 - 1868
SICI:
0270-6474(1998)18:5<1860:AOSNIT>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING CATS; RAT SPINAL-CORD; BRAIN-STEM; DIFFERENTIAL RELEASE; INDUCED ANTINOCICEPTION; ELECTRICAL-STIMULATION; SYSTEMIC MORPHINE; SUBSTANCE-P; 5-HYDROXYTRYPTAMINE; PATHWAYS;
Keywords:
PAIN MODULATION; NOCICEPTION; ANTINOCICEPTION; MONOAMINES; SEROTONIN; DISCHARGE PATTERN; MORPHINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
K.M. Gao et al., "ACTIVATION OF SEROTONERGIC NEURONS IN THE RAPHE MAGNUS IS NOT NECESSARY FOR MORPHINE ANALGESIA", The Journal of neuroscience, 18(5), 1998, pp. 1860-1868

Abstract

A wealth of pharmacological and behavioral data suggests that spinally projecting serotonergic cells mediate opioid analgesia. A populationof medullary neurons, located within raphe magnus (RM) and the neighboring reticular nuclei, contains serotonin and is the source of serotonin in the spinal dorsal horn, To test whether serotonergic neurons mediate opioid analgesia, morphine was administered during recordings from medullary cells that were physiologically characterized as serotonergic (5HT(p)) by their slow and steady discharge pattern in the lightly anesthetized rat. Selected 5HT(p) cells (n = 14) were intracellularly labeled, and all contained serotonin immunoreactivity. The dischargeof most 5HT(p) cells was not affected by an analgesic dose of systemic morphine. In a minority of cases, 5HT(p) cells either increased or decreased their discharge after morphine administration. However, morphine altered the discharge of some 5HT(p) cells in the absence of producing analgesia and conversely did not alter the discharge of most 5HT(p) cells in cases in which analgesia occurred, RM cells with irregulardischarge patterns and excitatory or inhibitory responses to noxious tail heat were classified as ON and OFF cells, respectively, All ON and OFF cells that were intracellularly labeled (n = 9) lacked serotoninimmunoreactivity. All ON cells were inhibited, and most OFF cells were excited by systemic morphine. Because 5HT(p) cells do not consistently change their discharge during morphine analgesia, they are unlikelyto mediate the analgesic effects of morphine, Instead, nonserotonergic cells are likely to mediate morphine analgesia in the anesthetized rat, In light of the sensitivity of morphine analgesia to manipulationsof serotonin, serotonin release, although neither necessary nor sufficient for opioid analgesia, is proposed to facilitate the analgesic effects of nonserotonergic RM terminals in the spinal cord.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:45:07