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Titolo:
INFLUENCE OF EXCITATORY AMINO-ACIDS ON BASAL AND SENSORY STIMULI-INDUCED RELEASE OF 5-HT IN THE LOCUS-COERULEUS
Autore:
SINGEWALD N; KAEHLER ST; HEMEIDA R; PHILIPPU A;
Indirizzi:
INNSBRUCK UNIV,DEPT PHARMACOL & TOXICOL,PETER MAYR STR 1 A-6020 INNSBRUCK AUSTRIA
Titolo Testata:
British Journal of Pharmacology
fascicolo: 4, volume: 123, anno: 1998,
pagine: 746 - 752
SICI:
0007-1188(1998)123:4<746:IOEAOB>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
DORSAL RAPHE NUCLEUS; RAT-BRAIN; MIDBRAIN RAPHE; SEROTONERGIC INNERVATION; TRYPTOPHAN-HYDROXYLASE; CARDIOVASCULAR STIMULI; AFFERENT-PROJECTIONS; GLUTAMATE RECEPTORS; CERULEUS NEURONS; ANESTHETIZED RAT;
Keywords:
5-HYDROXYTRYPTAMINE (5-HT) RELEASE; LOCUS COERULEUS; NMDA; KAINIC ACID; AP5; KYNURENIC ACID; DNQX; GLUTAMATE; TAIL PINCH; NOISE STRESS; PUSH-PULL SUPERFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
N. Singewald et al., "INFLUENCE OF EXCITATORY AMINO-ACIDS ON BASAL AND SENSORY STIMULI-INDUCED RELEASE OF 5-HT IN THE LOCUS-COERULEUS", British Journal of Pharmacology, 123(4), 1998, pp. 746-752

Abstract

1 The interactions between 5-hydroxytryptaminergic neurones and excitatory amino acid utilizing neurones were studied in the locus coeruleus of conscious, freely moving rats. The locus coeruleus was superfusedwith artificial cerebrospinal fluid through a push-pull cannula and 5-hydroxytryptamine (5-HT) was determined in the superfusate that was continuously collected in time periods of 10 min. 2 Superfusion of the locus coeruleus with the NMDA receptor antagonist AP5 (10 mu M), kynurenic acid (1 mM), or the AMPA/kainate receptor antagonist DNQX (10 mu M) reduced the 5-HT release in the locus coeruleus. 3 Superfusion withthe agonists NMDA (50 mu M), kainic acid (50 mu M) or AMPA (10 mu M) enhanced the release rate of 5-HT. AP5 (10 mu M) blocked the stimulanteffect of NMDA, while tetrodotoxin (1 mu M) failed to influence the NMDA-induced release of 5-HT. In the presence of 10 mu M DNQX, the releasing effect of 50 mu M kainic acid was abolished. 4 Pain elicited by tail pinch, as well as noise-induced stress, increased the release of 5-HT. Superfusion of the locus coeruleus with 10 mu M AP5 reduced the tail pinch-induced 5-HT release. AP5 (10 mu M) did not affect the noise-induced release of 5-HT which was reduced, when the locus coeruleus was superfused simultaneously with this concentration of AP5 and 1 mu M kynurenic acid. DNQX (10 mM) failed to influence the release of 5-HTinduced by tail pinch or noise. 5 The findings suggest that 5-hydroxytryptaminergic neurones of the locus coeruleus are tonically modulatedby excitatory amino acids via NMDA and AMPA/kainate receptors. The release of 5-HT elicited by tail pinch and noise is mediated to a considerable extent through endogenous excitatory amino acids acting on NMDAreceptors, while AMPA/kainate receptors are not involved in this process.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:25:12