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Titolo:
INTRACRANIAL AND SPINAL DISSEMINATION OF AN ACTH-SECRETING PITUITARY NEOPLASIA - CASE-REPORT AND REVIEW OF LITERATURE
Autore:
DELLACASA S; CORSELLO SM; SATTA MA; ROTA CA; PUTIGNANO P; VANGELI V; COLOSIMO C; ANILE C; BARBARINO A;
Indirizzi:
UNIV SACRED HEART,SCH MED,INST ENDOCRINOL,LARGO A GEMELLI 8 I-00168 ROME ITALY UNIV SACRED HEART,SCH MED,INST RADIOL I-00168 ROME ITALY UNIV SACRED HEART,SCH MED,INST NEUROSURG I-00168 ROME ITALY
Titolo Testata:
Annales d'Endocrinologie
fascicolo: 6, volume: 58, anno: 1997,
pagine: 503 - 509
SICI:
0003-4266(1997)58:6<503:IASDOA>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
CUSHINGS-SYNDROME; CARCINOMA; METASTASES; TUMOR; ADRENOCORTICOTROPIN; ADENOMAS; PATIENT; LIVER;
Keywords:
ACTH; PITUITARY NEOPLASIA; PITUITARY CARCINOMA;
Tipo documento:
Review
Natura:
Periodico
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S. Dellacasa et al., "INTRACRANIAL AND SPINAL DISSEMINATION OF AN ACTH-SECRETING PITUITARY NEOPLASIA - CASE-REPORT AND REVIEW OF LITERATURE", Annales d'Endocrinologie, 58(6), 1997, pp. 503-509

Abstract

We report a case of a 52-year-old woman presenting with a recurrence of a large pituitary adenoma with suprasellar extension and an overt Cushing's clinical picture, five years after successful transsphenoidaltreatment. After transfrontal ablation of the tumour, followed by external radiotherapy, she was asymptomatic for six years before she exhibited epileptic seizures. A left frontal intracranial neoplasm was diagnosed and removed, and at histological examination it was found to beconstituted by a localization of the pituitary ACTH secreting neoplasia. One month later she exhibited spinal dissemination of the ACTH secreting neoplasia which was only partially removed. After four months aMagnetic Resonance Image (MRI) revealed recurrence of the intracranial localization and further spinal dissemination. Because of compressive symptoms, spinal masses with the same histologic features, were partially removed again in three successive surgical operations. Several medical treatments for obtaining the control of corticoid excess, caused by the ACTH overproduction, were tried, but none were satisfactory. Finally a bilateral adrenal venous embolization was performed thus obtaining a critical transient fall of serum cortisol. Five months later the patient died. At necroscopy bilateral adrenal enlargement was found, spinal disseminations were confirmed, and no metastatic lesions were discovered.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:18:57