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Titolo:
2 MEMBERS OF THE TCF FAMILY IMPLICATED IN WNT BETA-CATENIN SIGNALING DURING EMBRYOGENESIS IN THE MOUSE/
Autore:
KORINEK V; BARKER N; WILLERT K; MOLENAAR M; ROOSE J; WAGENAAR G; MARKMAN M; LAMERS W; DESTREE O; CLEVERS H;
Indirizzi:
UNIV UTRECHT HOSP,DEPT IMMUNOL,POB 85500 NL-3508 GA UTRECHT NETHERLANDS UNIV UTRECHT HOSP,DEPT IMMUNOL NL-3508 GA UTRECHT NETHERLANDS UNIV UTRECHT HOSP,NETHERLANDS INST DEV BIOL,HUBRECHT LAB NL-3584 CX UTRECHT NETHERLANDS UNIV UTRECHT HOSP,DEPT HEMATOL NL-3584 CX UTRECHT NETHERLANDS UNIV AMSTERDAM,DEPT ANAT & EMBRYOL NL-1105 AZ AMSTERDAM NETHERLANDS STANFORD UNIV,HOWARD HUGHES MED INST,SCH MED STANFORD CA 94305
Titolo Testata:
Molecular and cellular biology
fascicolo: 3, volume: 18, anno: 1998,
pagine: 1248 - 1256
SICI:
0270-7306(1998)18:3<1248:2MOTTF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRANSCRIPTION FACTOR LEF-1; MAMMARY EPITHELIAL-CELLS; BETA-CATENIN; HMG-BOX; INT-1 PROTOONCOGENE; TARGETED DISRUPTION; ONCOGENE INT-1; ALPHA-ENHANCER; WNT FAMILY; EXPRESSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
V. Korinek et al., "2 MEMBERS OF THE TCF FAMILY IMPLICATED IN WNT BETA-CATENIN SIGNALING DURING EMBRYOGENESIS IN THE MOUSE/", Molecular and cellular biology, 18(3), 1998, pp. 1248-1256

Abstract

Tcf transcription factors interact with beta-catenin and Armadillo tomediate Wnt/Wingless signaling. We now report the characterization ofgenes encoding two murine members of the Tcf family, mTcf-3 and mTCf-4. mTCf-3 mRNA is ubiquitously present in embryonic day 6.5 (E6.5) mouse embryos but gradually disappears over the next 3 to 4 days. mTcf-4 expression occurs first at E10.5 and is restricted to di-and mesencephalon and the intestinal epithelium during embryogenesis. The mTcf-3 and mTcf-4 proteins bind ii canonical Tcf DNA motif and can complex withthe transcriptional coactivator beta-catenin. Overexpression of Wnt-1in a mammary epithelial cell line leads to the formation of a nuclearcomplex between beta-catenin and Tcf proteins and to Tcf reporter gene transcription. These data demonstrate a direct link between Wnt stimulation and beta-catenin/Tcf transcriptional activation and imply a role for mTcf-3 and -4 in early Wnt driven developmental decisions in the mouse embryo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:50:09