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Titolo:
HEME OXYGENASE IS INDUCED IN NEPHROTOXIC NEPHRITIS AND HEMIN, A STIMULATOR OF HEME OXYGENASE SYNTHESIS, AMELIORATES DISEASE
Autore:
MOSLEY K; WEMBRIDGE DE; CATTELL V; COOK HT;
Indirizzi:
HAMMERSMITH HOSP,ROYAL POSTGRAD MED SCH,DEPT HISTOPATHOL,DU CANE RD LONDON W12 0NN ENGLAND ST MARYS HOSP,IMPERIAL COLL SCH MED,DEPT HISTOPATHOL & EXPT PAHTOL LONDON ENGLAND
Titolo Testata:
Kidney international
fascicolo: 3, volume: 53, anno: 1998,
pagine: 672 - 678
SICI:
0085-2538(1998)53:3<672:HOIIIN>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALBUMIN-BOUND BILIRUBIN; NITRIC-OXIDE; ENDOTHELIAL-CELLS; GLOMERULAR INJURY; MESANGIAL CELLS; BINDING-SITES; RENAL INJURY; HEAT-SHOCK; RAT; ANTIOXIDANT;
Keywords:
HEME OXYGENASE; INFLAMMATION; NEPHROTOXIC NEPHRITIS; PROTEINURIA; OXIDATIVE STRESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
K. Mosley et al., "HEME OXYGENASE IS INDUCED IN NEPHROTOXIC NEPHRITIS AND HEMIN, A STIMULATOR OF HEME OXYGENASE SYNTHESIS, AMELIORATES DISEASE", Kidney international, 53(3), 1998, pp. 672-678

Abstract

Heme oxygenase (HO) catalyses degradation of heme to biliverdin, ironand carbon monoxide (CO). Two isoforms exist, a constitutive form andan inducible form (HO-1). Induction of HO-1 may have protective effects in inflammation. We studied heterologous (HNTN) and accelerated (ANTN) nephrotoxic nephritis in Lewis rats. Hemin. an inducer of HO-1. (30 mu mol/kg) was administered 18 hours before induction of nephritis and 72 hours later in ANTN. HO-1 was not detected immunohistochemicallyin normal glomeruli but was present in HNTN and ANTN in cells with the morphology of macrophages. HO-1 induction was confirmed by RT-PCR. In normal rats hemin induced glomerular HO-1 mRNA at 18 hours. In HNTN hemin markedly reduced proteinuria at 24 hours (10 +/- 4 mg/24 hr; control 54 +/- 16; P < 0.05), neutrophil infiltration at two hours (29.8 /- 1.8 vs. 22.3 +/- 1.5 neutrophils/glomerulus, P < 0.05), and glomerular macrophage number at two hours (2.1 +/- 0.1 vs. 3.1 +/- 0.4 cells/glomerulus, P < 0.05). In ANTN proteinuria was reduced al dal; 1 and day 4 (36 +/- 11 vs. 60 +/- 15 and 35 +/- 7 vs. 86 +/- 9 mg protein/24hr, respectively, P < 0.001), glomerular thrombi were reduced by hemin at day 1 and 4 (1.5 +/- 2.7 vs. 3.7 +/- 0.2 and 1.3 +/- 0.01 vs. 2.9+/- 0.02, respectively. P < 0.001) and glomerular macrophage infiltration was reduced on day 4 (11.2 +/- 0.8 cells/glom; control 15.9 +/- 0.8, P < 0.01). Possible mechanisms by which HO-1 ameliorates disease include anti-complement or anti-oxidant effects of bilirubin and vasodilator and anti-platelet effects of carbon monoxide.

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Documento generato il 04/12/20 alle ore 20:07:04