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Titolo:
PATTERNS OF REGIONAL CORTICAL DYSMORPHOLOGY DISTINGUISHING SCHIZOPHRENIA AND CHRONIC-ALCOHOLISM
Autore:
SULLIVAN EV; MATHALON DH; LIM KO; MARSH L; PFEFFERBAUM A;
Indirizzi:
STANFORD UNIV,SCH MED,DEPT PSYCHIAT & BEHAV SCI STANFORD CA 94305 VA PALO ALTO HLTH CARE SYST PALO ALTO CA 00000 SRI INT,NEUROPSYCHIAT PROGRAM MENLO PK CA 94025
Titolo Testata:
Biological psychiatry
fascicolo: 2, volume: 43, anno: 1998,
pagine: 118 - 131
SICI:
0006-3223(1998)43:2<118:PORCDD>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRAY-MATTER VOLUME; SUPERIOR TEMPORAL GYRUS; CEREBRAL BLOOD-FLOW; DORSOLATERAL PREFRONTAL CORTEX; SPATIAL WORKING MEMORY; FRONTAL-LOBE FUNCTION; CARD SORTING TEST; BRAIN MORPHOLOGY; 1ST-EPISODE SCHIZOPHRENIA; STRUCTURAL ABNORMALITIES;
Keywords:
MAGNETIC RESONANCE IMAGING; ALCOHOLISM; SCHIZOPHRENIA; CORTICAL GRAY MATTER; WHITE MATTER; VENTRICLES; BRAIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
106
Recensione:
Indirizzi per estratti:
Citazione:
E.V. Sullivan et al., "PATTERNS OF REGIONAL CORTICAL DYSMORPHOLOGY DISTINGUISHING SCHIZOPHRENIA AND CHRONIC-ALCOHOLISM", Biological psychiatry, 43(2), 1998, pp. 118-131

Abstract

Background: This study used magnetic resonance imaging (MRI) to compare the extent and pattern of tissue volume deficit and cerebrospinal fluid volume enlargement in chronic alcoholics and schizophrenics. Methods: The subjects included 62 detoxified chronic alcoholics (26-63 years), 71 schizophrenics (23-63 years), and 73 controls spanning the adult age range (21-70 years), MRI volumes were adjusted for normal variation in head size and age established from the central group. Results:Both patient groups showed widespread cortical gray matter volume deficits compared with controls, but only the alcoholics had white mattervolume deficits. The schizophrenics had significantly greater volume deficits in the prefrontal and anterior superior temporal gray matter than in the more posterior cortical regions. By contrast, the deficitsin the alcoholics were relatively homogeneous across the cortex. For white matter, the deficits in the alcoholics were greatest in the prefrontal and temporal-parietal regions. Although both patient groups hadabnormally larger cortical sulci and lateral and third ventricles than the controls, the alcoholics had significantly larger sulcal volumesin the frontal, anterior, and posterior parietal-occipital regions than the schizophrenics. Conclusions: This quantitative MRI study revealed different patterns of regional cortical volume abnormalities in schizophrenics and alcoholics. The schizophrenic group exhibited corticalgray matter volume deficits of modestly greater magnitude than that observed in the alcoholic group, and the alcoholics bur not the schizophrenics exhibited cortical white matter volume deficits. (C) 1998 Society of Biological Psychiatry.

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Documento generato il 27/01/20 alle ore 01:32:37