Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
EVALUATION OF REGIONAL MYOCARDIAL PERFUSION IN PATIENTS WITH SEVERE LEFT-VENTRICULAR DYSFUNCTION - COMPARISON OF N-13 AMMONIA PET AND TC-99M SESTAMIBI SPECT
Autore:
SAND NPR; BOTTCHER M; MADSEN MM; NIELSEN TT; REHLING M;
Indirizzi:
AARHUS UNIV HOSP,DEPT NUCL MED,SKEJBY SYGEHUS DK-8200 AARHUS N DENMARK AARHUS UNIV HOSP,PET CTR,SKEJBY SYGEHUS DK-8200 AARHUS N DENMARK AARHUS UNIV HOSP,DEPT CARDIOL,SKEJBY SYGEHUS DK-8200 AARHUS N DENMARK
Titolo Testata:
Journal of nuclear cardiology
fascicolo: 1, volume: 5, anno: 1998,
pagine: 4 - 13
SICI:
1071-3581(1998)5:1<4:EORMPI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; CORONARY-ARTERY DISEASE; COMPUTED-TOMOGRAPHY; TL-201 SPECT; BLOOD-FLOW; VIABILITY; REST; REPRODUCIBILITY; ISONITRILE; EXERCISE;
Keywords:
MYOCARDIAL PERFUSION; LEFT VENTRICULAR DYSFUNCTION; N-13 AMMONIA PET; TC-99M-SESTAMIBI SPECT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
N.P.R. Sand et al., "EVALUATION OF REGIONAL MYOCARDIAL PERFUSION IN PATIENTS WITH SEVERE LEFT-VENTRICULAR DYSFUNCTION - COMPARISON OF N-13 AMMONIA PET AND TC-99M SESTAMIBI SPECT", Journal of nuclear cardiology, 5(1), 1998, pp. 4-13

Abstract

Objective. Positron emission tomography (PET) scanning with N-13-ammonia and (18)FDG is well established for the detection of myocardial viability, Due to the limited availability of PET facilities, recent studies have combined technetium 99m sestamibi single photon emission computed tomography (SPECT) with (18)FDG PET or (18)FDG SPECT, This approach enables simultaneous assessment of regional myocardial blood flow and metabolism and substantially increases the capacity for viability detection, To validate whether Tc-99m-Sestamibi SPECT can replace N-13-ammonia PET, we compared these two modalities in patients with severeleft ventricular dysfunction due to coronary artery disease. Materials and Methods. Thirty-one patients (mean age 57 +/- 8 years; mean ejection fraction 27% +/- 8%) with angiographically verified coronary artery disease were included, In random order, ammonia-PET and sestamibi-SPECT scans were performed, In a 20-segment model of the left ventricle, two blinded observers scored a total of 610 segments on a five-pointscale, In a subset of 20 patients, 400 segments were scored twice to evaluate the observer variations of the two techniques, Segmental score differences were used to compare the imaging modalities, The impact on viability detection was assessed by combining the two flow tracers with FDG PET. Results, Segmental comparison of the PET and SPECT studies yielded similar (difference less than or equal to 1) results in 74%of segments, reflecting regional concordance values in the lateral, apical, anterior, septal, and inferior myocardial walls of 86%, 82%, 71%, 66%, and 63%, respectively, The differences in the septal and inferior walls mere primarily due to overestimation of perfusion defects bysestamibi SPECT, which yielded a higher proportion of mismatch patterns in those regions, The overall observer variations of the PET and SPECT studies were 7.5% and 5.8%. Conclusion. Myocardial perfusion imaging with N-13-ammonia PET and Tc-99m-sestamibi SPECT yielded similar results in patients with severe left ventricular dysfunction, except forthe septal and inferior regions, In these regions, SPECT tended to overestimate perfusion defects, Hence, attenuation correction should be considered when combining FDG PET and sestamibi SPECT for diagnosing myocardial viability to avoid overestimation of mismatch patterns in those regions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/01/20 alle ore 19:14:11