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Titolo:
PRESENCE OF PUTATIVE NEUROTRANSMITTERS IN THE MYENTERIC PLEXUS OF THEGASTROINTESTINAL-TRACT AND IN THE MUSCULATURE OF THE URINARY-BLADDER OF THE FERRET
Autore:
SANN H; HOPPE S; BALDWIN L; GRUNDY D; SCHEMANN M;
Indirizzi:
TIERARZTLICHEN HSCH HANNOVER,INST PHYSIOL,BISCHOFSHOLER DAMM 15-102 D-30173 HANNOVER GERMANY TIERARZTLICHEN HSCH HANNOVER,INST PHYSIOL D-30173 HANNOVER GERMANY UNIV SHEFFIELD,DEPT BIOMED SCI SHEFFIELD S10 2TN S YORKSHIRE ENGLAND
Titolo Testata:
Neurogastroenterology and motility
fascicolo: 1, volume: 10, anno: 1998,
pagine: 35 - 47
SICI:
1350-1925(1998)10:1<35:POPNIT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENTERIC NERVOUS-SYSTEM; GENE-RELATED PEPTIDE; PIG SMALL-INTESTINE; PORCINE SMALL-INTESTINE; GUINEA-PIG; NEUROPEPTIDE-Y; AUTONOMIC INNERVATION; COUNT NEURONS; RAT; GANGLIA;
Keywords:
CALCITONIN-GENE-RELATED PEPTIDE; CHOLINE ACETYLTRANSFERASE; DOPAMINE-BETA-HYDROXYLASE; ENTERIC NERVOUS SYSTEM; NEUROPEPTIDE Y; NITRIC OXIDE SYNTHASE; SUBSTANCE P; VASOACTIVE INTESTINAL POLYPEPTIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
H. Sann et al., "PRESENCE OF PUTATIVE NEUROTRANSMITTERS IN THE MYENTERIC PLEXUS OF THEGASTROINTESTINAL-TRACT AND IN THE MUSCULATURE OF THE URINARY-BLADDER OF THE FERRET", Neurogastroenterology and motility, 10(1), 1998, pp. 35-47

Abstract

The innervation of the musculature in the ferret stomach, ileum, colon and urinary bladder was investigated using immunohistochemistry in noncolchicin-treated tissues. In the gastrointestinal tract two main subpopulations of myenteric neurones were found: cholinergic neurones expressing choline acetyltransferase (ChAT), which made up 68, 67 and 67% of the neurones in the stomach, ileum and colon, respectively, and nitrergic neurones containing nitric oxide synthase and NADPH-diaphorase (stomach: 23%, ileum: 21%, colon: 26%). In the stomach, cholinergic neurones expressed substance P (SP, 2% of all neurones), dopamine-beta-hydroxylase (DBH, 19%) but not tyrosine hydroxylase (TH) or vasoactive intestinal polypeptide (VIP), while nitrergic neurones contained VIPand neuropeptide Y (NPY). TH-but not DBH-immunoreactivity was observed in 4% of gastric neurones. Intense immunoreactivity in the musculature suggests that part of ChAT/SP- and NOS/NPY/VIP-positive neurones function as motorneurones. In the ileum, a high number (32%) of DBH-positive neurones was demonstrated. About half of the SP-positive neuronesin the ileum also contained calcitonin generated peptide (CGRP). In the urinary bladder, only few intramural ganglia were observed. The smooth muscle was densely innervated by ChAT, NPY and DBH immunoreactive fibres. The data showed that the innervation of the ferret viscera exhibited similarities but also differences as compared with other mammalian species. Some of the chemical coding of myenteric neurones is remarkably similar to that observed in other mammals.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 14:22:49