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Titolo:
TTF-1 PROTEIN EXPRESSION IN PLEURAL MALIGNANT MESOTHELIOMAS AND ADENOCARCINOMAS OF THE LUNG
Autore:
DILORETO C; PUGLISI F; DILAURO V; DAMANTE G; BELTRAMI CA;
Indirizzi:
IST ANAT PATOL,PLE S MARIA MARIA MISERICORDIA I-33100 UDINE ITALY UNIV UDINE,DEPT ANAT PATHOL I-33100 UDINE ITALY UNIV UDINE,POSTGRAD SCH ONCOL I-33100 UDINE ITALY UNIV UDINE,DEPT GENET I-33100 UDINE ITALY
Titolo Testata:
Cancer letters
fascicolo: 1, volume: 124, anno: 1998,
pagine: 73 - 78
SICI:
0304-3835(1998)124:1<73:TPEIPM>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYROID TRANSCRIPTION FACTOR-1; IMMUNOHISTOCHEMICAL EVALUATION; PULMONARY ADENOCARCINOMA; FACTOR-I; DIAGNOSIS; DIFFERENTIATION; GENE; DISTINCTION; ANTIBODIES; CARCINOMAS;
Keywords:
TTF-1 PROTEIN; IMMUNOHISTOCHEMISTRY; PLEURAL MALIGNANT MESOTHELIOMA; LUNG ADENOCARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
C. Diloreto et al., "TTF-1 PROTEIN EXPRESSION IN PLEURAL MALIGNANT MESOTHELIOMAS AND ADENOCARCINOMAS OF THE LUNG", Cancer letters, 124(1), 1998, pp. 73-78

Abstract

TTF-1 is a tissue-specific transcription factor expressed in the epithelial cells of thyroid and lung. This study investigates the immunohistochemical expression of TTF-I in pleural malignant mesotheliomas (MM) and adenocarcinomas (AC) of the lung, respectively. For this purpose, 33 biopsy specimens of pulmonary AC and 24 specimens of MM were studied, TTF-1 immunoreactivity was identified in 19 of 33 cases of AC (57.5%) and in none of the 24 cases of MM. Positivity for TTF-1 was 100% specific and 57.5% sensitive for lung AC, Alternatively, negativity for TTF-1 was 57.5% specific and 100% sensitive for MM. These results suggest that TTF-I can be favourably added to the immunohistochemical diagnostic panel for distinction between AC of the lung involving the pleura and pleural MM. (C) 1998 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 04:53:04