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Titolo:
STRAND SCISSION IN DNA INDUCED BY CURCUMIN IN THE PRESENCE OF CU(II)
Autore:
AHSAN H; HADI SM;
Indirizzi:
ALIGARH MUSLIM UNIV,FAC LIFE SCI,DEPT BIOCHEM ALIGARH 202002 UTTAR PRADESH INDIA ALIGARH MUSLIM UNIV,FAC LIFE SCI,DEPT BIOCHEM ALIGARH 202002 UTTAR PRADESH INDIA
Titolo Testata:
Cancer letters
fascicolo: 1, volume: 124, anno: 1998,
pagine: 23 - 30
SICI:
0304-3835(1998)124:1<23:SSIDIB>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
OXYGEN-FREE-RADICALS; ANTIOXIDANTS; QUERCETIN; DAMAGE; METABOLITES; DISEASE; FLUIDS; COPPER; ACID; IRON;
Keywords:
CURCUMIN; DNA CLEAVAGE; CU(II) REDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
32
Recensione:
Indirizzi per estratti:
Citazione:
H. Ahsan e S.M. Hadi, "STRAND SCISSION IN DNA INDUCED BY CURCUMIN IN THE PRESENCE OF CU(II)", Cancer letters, 124(1), 1998, pp. 23-30

Abstract

Curcumin, a naturally occurring phytochemical responsible for the colour of turmeric, has shown a wide range of pharmacological properties including anti-inflammatory, anti-tumour promoter and anti-oxidant effects. In this paper we show that in the presence of Cu(II), curcumin caused breakage of calf thymus and supercoiled plasmid pBR322 DNA. The products were relaxed circles with no detectable linear forms. Other metal ions tested (Mg(II), Ca(II), Fe(LI) and Ni(II)) were ineffective or less effective in the DNA breakage reaction. Cu(I) was shown to be an essential intermediate by using the Cu(I)-specific sequestering reagent neocuproine. The involvement of active oxygen species, such as H2O2 and O-1(2) was established by the inhibition of DNA breakage by catalase and azide. Curcumin is also able to directly produce O-2(-) and H2O2 and in the presence of Cu(II), OH. is generated. Absorption spectra of curcumin in the presence of DNA indicated that a complex is formed between the two. The results are discussed in relation to the established pro-oxidant activities of other known anti-oxidants. (C) 1998 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/12/20 alle ore 12:33:37