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Titolo:
QUANTIFICATION OF PHOSPHORUS METABOLITES FROM CHEMICAL-SHIFT IMAGING SPECTRA WITH CORRECTIONS FOR POINT-SPREAD EFFECTS AND B-1 INHOMOGENEITY
Autore:
MURPHYBOESCH J; JIANG H; STOYANOVA R; BROWN TR;
Indirizzi:
FOX CHASE CANC CTR,INST CANC RES,DEPT NMR & MED SPECT,7701 BURHOLME AVE PHILADELPHIA PA 19111
Titolo Testata:
Magnetic resonance in medicine
fascicolo: 3, volume: 39, anno: 1998,
pagine: 429 - 438
SICI:
0740-3194(1998)39:3<429:QOPMFC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR MAGNETIC-RESONANCE; HIGH-ENERGY PHOSPHATES; HUMAN CALF MUSCLE; SURFACE-COIL NMR; TO-NOISE RATIO; HUMAN-BRAIN; P-31 NMR; SPECTROSCOPY; INVIVO; QUANTITATION;
Keywords:
QUANTIFICATION; CHEMICAL SHIFT IMAGING; PHOSPHORUS METABOLITES; MAGNETIC RESONANCE SPECTROSCOPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
J. Murphyboesch et al., "QUANTIFICATION OF PHOSPHORUS METABOLITES FROM CHEMICAL-SHIFT IMAGING SPECTRA WITH CORRECTIONS FOR POINT-SPREAD EFFECTS AND B-1 INHOMOGENEITY", Magnetic resonance in medicine, 39(3), 1998, pp. 429-438

Abstract

A method is described for quantifying phosphorus metabolites in tissue using spectra localized with surface coils and chemical shift imaging (CSI) and assuming that metabolites are uniformly distributed withina well-defined volume, An analytical expression is developed that yields a single numerical correction factor that takes into account the excitation and receiver profiles of the coil, T-1 saturation, and pointspread effects associated with Fourier transformation of CSI data, Anexternal phosphorus standard is used to calibrate instrument gain andthe B-1 profile of the coil. For spherical samples, point spread effects can modulate the signal intensities of three-dimensional CSI spectra from -32% to +54%, depending on the voxel size. Measurements of phantoms of known concentrations showed systematic variations of +/- 10% and random errors of +/- 5%. We have used this method to measure the concentration of phosphocreatine in the thigh muscle of normal volunteers.

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Documento generato il 09/07/20 alle ore 01:31:25