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Titolo:
ACUTE EFFECTS OF CELIPROLOL ON MUSCLE BLOOD-FLOW AND INSULIN SENSITIVITY - STUDIES USING [O-15]-WATER, [F-18] FLUORODEOXYGLUCOSE AND POSITRON EMISSION TOMOGRAPHY
Autore:
MALMINIEMI K; LAINE H; KNUUTI MJ; RUOTSALAINEN U; OIKONEN V; HAAPARANTA M; NUUTILA P;
Indirizzi:
LEIRAS,POB 33 FIN-33721 TAMPERE FINLAND TAMPERE UNIV HOSP FIN-33521 TAMPERE FINLAND UNIV TURKU,DEPT MED FIN-20520 TURKU FINLAND TURKU PET CTR FIN-20520 TURKU FINLAND ABO AKAD UNIV,ACCELERATOR LAB FIN-20520 TURKU FINLAND
Titolo Testata:
European Journal of Clinical Pharmacology
fascicolo: 1, volume: 52, anno: 1997,
pagine: 19 - 26
SICI:
0031-6970(1997)52:1<19:AEOCOM>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKELETAL-MUSCLE; HYPERTENSIVE PATIENTS; RESISTANCE; FOREARM; HEART; NOREPINEPHRINE; VASODILATION; ACTIVATION; MECHANISM; SECRETION;
Keywords:
MUSCLE BLOOD FLOW; POSITRON EMISSION TOMOGRAPHY; INSULIN SENSITIVITY; EUGLYCEMIC CLAMP; FLUORODEOXYGLUCOSE; CELIPROLOL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
K. Malminiemi et al., "ACUTE EFFECTS OF CELIPROLOL ON MUSCLE BLOOD-FLOW AND INSULIN SENSITIVITY - STUDIES USING [O-15]-WATER, [F-18] FLUORODEOXYGLUCOSE AND POSITRON EMISSION TOMOGRAPHY", European Journal of Clinical Pharmacology, 52(1), 1997, pp. 19-26

Abstract

Objective: Recently the role of peripheral vasoconstriction in the aetiology of insulin resistance has been proposed. Celiprolol is a beta(1)-selective adrenoceptor antagonist with partial agonist activity at the beta(2)-receptor as well as vasodilator properties. The acute effects of celiprolol on skeletal muscle blood flow and insulin sensitivity were measured in this study. Methods: Celiprolol (2 times 0.5 mg.kg(-1)) or saline was given intravenously to five healthy males in randomorder. Muscle blood flow was measured in femoral regions using [O-15]-labelled water and positron emission tomography (PET) during euglycaemic hyperinsulinaemia (serum insulin similar to 65 mU.l(-1)) after an overnight fast. Thereafter, skeletal and heart muscle glucose uptake were determined using [F-18]-2-deoxy-D-glucose. Results: Celiprolol increased muscle blood flow by 74%, from 3.4 to 5.9 ml.min(-1).100 g(-1) muscle in the basal state. It decreased peripheral resistance by 40%, from 32.0 to 19.2 mmHg.ml(-1).min(-1).100 g(-1). Celiprolol significantly decreased diastolic blood pressure from 82 to 73 mmHg and increased heart rate from 61 to 68 beats.min(-1), which suggests sympathetic activation. Insulin-stimulated glucose uptake was reduced by 46% in thewhole body, from 39 to 21 mu mol.kg(-1).min(-1) and by 59% in the femoral muscles, from 99 to 41 mu mol.kg(-1).min(-1), with celiprolol as compared to saline. The effect on heart glucose uptake did not statistically differ between the treatments. Conclusion: Celiprolol given intravenously increased muscle blood flow and decreased peripheral resistance at rest. It also acutely increased heart rate probably via sympathetic activation, and decreased insulin sensitivity in the muscles of healthy male volunteers. The enhanced muscle perfusion when celiprololis given intravenously does not explain the improved insulin sensitivity seen in the long-term oral use in dyslipidaemic hypertensive patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 17:24:54