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Titolo:
HUMAN CD4(-LYMPHOCYTES RECOGNIZE A HIGHLY CONSERVED EPITOPE OF HUMAN T-LYMPHOTROPIC-VIRUS TYPE-1 (HTLV-1) ENV GP21 RESTRICTED BY HLA DRB1-ASTERISK-0101() T)
Autore:
KITZE B; USUKU K; YAMANO Y; YASHIKI S; NAKAMURA M; FUJIYOSHI T; IZUMO S; OSAME M; SONODA S;
Indirizzi:
UNIV GOTTINGEN,DEPT NEUROL,ROBERT KOCH STR 40 D-37075 GOTTINGEN GERMANY KYUSHU UNIV,FAC MED,DEPT INTERNAL MED 1 FUKUOKA 812 JAPAN KAGOSHIMA UNIV,FAC MED,DEPT VIROL KAGOSHIMA 890 JAPAN KAGOSHIMA UNIV,FAC MED,DEPT INTERNAL MED 3 KAGOSHIMA 890 JAPAN KAGOSHIMA UNIV,FAC MED,CTR CHRON VIRAL DIS KAGOSHIMA 890 JAPAN
Titolo Testata:
Clinical and experimental immunology
fascicolo: 2, volume: 111, anno: 1998,
pagine: 278 - 285
SICI:
0009-9104(1998)111:2<278:HCRAHC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
I-ASSOCIATED MYELOPATHY; TROPICAL SPASTIC PARAPARESIS; B-CELL EPITOPES; NEUROLOGICAL DISEASE; SYNTHETIC PEPTIDES; ENVELOPE; INDUCTION; LEUKEMIA; HAM/TSP; PROTEIN;
Keywords:
HTLV-1; T LYMPHOCYTES; EPITOPE; HLA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
B. Kitze et al., "HUMAN CD4(-LYMPHOCYTES RECOGNIZE A HIGHLY CONSERVED EPITOPE OF HUMAN T-LYMPHOTROPIC-VIRUS TYPE-1 (HTLV-1) ENV GP21 RESTRICTED BY HLA DRB1-ASTERISK-0101() T)", Clinical and experimental immunology, 111(2), 1998, pp. 278-285

Abstract

HTLV-1 causes two distinct human diseases, HTLV-l-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and adult T cell leukaemia/lymphoma (ATL). Persistently infected individuals carry a risk of <1% of developing either disease. These basic epidemiological data imply that virus-host interactions, especially immunogenetic factors, influence the outcome of infection. Several studies showed that the HLA class II DR1 DQ5 haplotype is over-represented in HAM/TSP, but rare in ATL. Therefore, we selected four patients with HAM/TSP and one seronegativecontrol who all carried the HLA DR1 DQ5 haplotype. We analysed the CD4(+) T lymphocyte response against eight synthetic peptides of HTLV-I envelope (env) glycoprotein gp21, a crucial target antigen in HAM/TSP. The first of two immunodominant epitopes corresponded to a domain of the HTLV-I envelope protein which had previously been shown to be essential for HTLV-1 envelope function. The second immunodominant epitope overlapped a highly conserved sequence of the retroviral transmembraneenvelope protein. DR1 (DRB10101)-restricted T lymphocytes were activated by the conserved peptide sequence in nanomolar concentrations. Incontrast, this conserved sequence can also induce non-specific, cAMP-mediated immunosuppressive effects on T cells when added in micromolarconcentrations to culture media, as shown by Haraguchi S, Good RA, James-Yarish M, Cianciulo GJ, Day NK, Proc Natl Acad Sci USA 1995 92:5568-71. Hence, HTLV-1 env gp21 might exert either stimulating immunological or immunosuppressive effects in HTLV-l-infected individuals, depending on the level of its expression and the presence of HLA DRB10101.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/09/20 alle ore 21:50:51