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Titolo:
EXPRESSION OF TRANSFORMING GROWTH-FACTOR-BETA RECEPTOR-TYPE-I AND TYPE-II IN RAT VENTRAL PROSTATE AND DUNNING R3327 PAP ADENOCARCINOMA IN RESPONSE TO CASTRATION AND ESTROGEN-TREATMENT
Autore:
WIKSTROM P; BERGH A; DAMBER JE;
Indirizzi:
UMEA UNIV,DEPT UROL & ANDROL S-90187 UMEA SWEDEN UMEA UNIV,DEPT UROL & ANDROL S-90187 UMEA SWEDEN UMEA UNIV,DEPT PATHOL S-90187 UMEA SWEDEN
Titolo Testata:
Urological research
fascicolo: 2, volume: 25, anno: 1997,
pagine: 103 - 111
SICI:
0300-5623(1997)25:2<103:EOTGRA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRAMMED CELL-DEATH; TGF-BETA; CANCER-CELLS; INHIBITORY RESPONSES; ESTROGEN-RECEPTOR; CARCINOMA-CELLS; TUMOR-GROWTH; FACTOR-BETA-1; RESISTANCE; CLONING;
Keywords:
TGF-BETA RECEPTORS; PROSTATE CANCER; COMPETITIVE POLYMERASE CHAIN REACTION; IMMUNOHISTOCHEMISTRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
P. Wikstrom et al., "EXPRESSION OF TRANSFORMING GROWTH-FACTOR-BETA RECEPTOR-TYPE-I AND TYPE-II IN RAT VENTRAL PROSTATE AND DUNNING R3327 PAP ADENOCARCINOMA IN RESPONSE TO CASTRATION AND ESTROGEN-TREATMENT", Urological research, 25(2), 1997, pp. 103-111

Abstract

In the normal prostate, transforming growth factor-beta 1 (TGF-beta 1) inhibits epithelial cell growth and is associated with apoptosis. The role of TGF-beta 1 in prostate cancer remains, however, unclear. In this work, the expression of TGF-beta receptor type I and II (TGFP-beta RI and TGF beta-RII) in the Dunning R3327 PAP adenocarcinoma was studied, after castration and oestrogen treatment. Since castration induces apoptosis in the rat ventral prostate (VP) [21], but not in the Dunning R3327 PAP tumour [46], the TGF-beta receptor levels in the tumourwere compared to the receptor levels in the VP. Methods used were competitive reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry. In the VP, TGF beta-RI and TGF beta-RII expressions were increased after castration, indicating a negative regulation of TGF beta receptors by androgens. In the Dunning tumour, TGF beta-RIand TGF beta-RII levels were elevated and only TGF beta-RI showed a clear-cut increase after castration. The receptors were located in epithelial and smooth muscle cells in the VP and mainly in epithelial cells in the Dunning tumour. In conclusion, the elevated TGF beta receptorlevels and the diminished androgen regulation of TGF beta-RII in the tumour distinguish the Dunning R3327 PAP tumour from the normal prostate and need to be further elucidated.

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Documento generato il 10/07/20 alle ore 02:41:19