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Titolo:
RENAL CU AND NA EXCRETION AND HEPATIC CU METABOLISM IN BOTH CU ACCLIMATED AND NON ACCLIMATED RAINBOW-TROUT (ONCORHYNCHUS-MYKISS)
Autore:
GROSELL MH; HOGSTRAND C; WOOD CM;
Indirizzi:
RISO NATL LAB,ENVIRONM SCI & TECHNOL DEPT,POB 49 DK-4000 ROSKILDE DENMARK UNIV KENTUCKY,TH MORGAN SCH BIOL SCI LEXINGTON KY 40506 MCMASTER UNIV,DEPT BIOL HAMILTON ON L8S 4K1 CANADA
Titolo Testata:
Aquatic toxicology
fascicolo: 2-3, volume: 40, anno: 1998,
pagine: 275 - 291
SICI:
0166-445X(1998)40:2-3<275:RCANEA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
SALMO-GAIRDNERI RICHARDSON; BILIARY-EXCRETION; COHO SALMON; COPPER; METALLOTHIONEIN; CERULOPLASMIN; ZINC; PH; KINETICS; SULFOBROMOPHTHALEIN;
Keywords:
CU-ACCLIMATION; RAINBOW TROUT (ONCORHYNCHUS MYKISS); CU-64; CU TURNOVER; CU EXCRETION; CU AND PLASMA-PROTEIN BINDING; METALLOTHIONEIN; RENAL NA+ REABSORPTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
41
Recensione:
Indirizzi per estratti:
Citazione:
M.H. Grosell et al., "RENAL CU AND NA EXCRETION AND HEPATIC CU METABOLISM IN BOTH CU ACCLIMATED AND NON ACCLIMATED RAINBOW-TROUT (ONCORHYNCHUS-MYKISS)", Aquatic toxicology, 40(2-3), 1998, pp. 275-291

Abstract

Cu-64 and,, total Cu accumulation were measured in gills, plasma, liver, kidney, bile and urine during 72 h of exposure to Cu-64, at 20 mu g Cu l(-1), in non-acclimated and Cu-acclimated (28 days of pre-exposure) rainbow trout (Oncorhynchus mykiss) fitted with urinary bladder catheters. Renal Cu excretion gradually declined from 0.03 mu g Cu kg(-1) h(-1) in non-exposed fish to 0.01 mu g Cu kg(-1) h(-1) after 28 daysof Cu exposure. A comparison of the Cu-64-labelled Cu and the total Cu excretion rates and the corresponding renal clearance revealed apparent differences in Cu binding to plasma protein depending on whether the Cu is derived from recent branchial uptake or is already present inthe plasma prior to Cu-64 exposure. The plasma Cu pool derived from recent branchial uptake and the Cu pool present in the plasma prior to Cu-64 exposure is accessible to renal excretion to different extents, whereas the pools seem equally accessible to hepatic accumulation and elimination. The renal Cu excretion is of minor importance compared with the hepatic Cu excretion, which was estimated to be 0.5-0.75 mu g Cu kg(-1) h(-1) and 1.1-1.6 mu g Cu kg(-1) h(-1) for non-acclimated andCu-acclimated fish, respectively. Based on the biliary Cu concentration, hepatic Cu elimination appeared to be stimulated in the Cu-acclimated relative to the non-acclimated fish. Only 17% and 12% of the hepatic Cu could be accounted for by metallothionein in the control and Cu-acclimated fish, respectively. Renal Na+ efflux decreased by 40%, which was largely due to increased tubular Na+ reabsorption. Renal compensation for the impaired branchial Na+ uptake, seen during Cu exposure, thus seems to be involved in Cu acclimation in rainbow trout. (C) 1998Elsevier Science B.V.

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Documento generato il 04/04/20 alle ore 08:38:59