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Titolo:
NEUROPROTECTIVE EFFECTS OF PTERIN-6-ALDEHYDE IN GERBIL GLOBAL BRAIN ISCHEMIA - COMPARISON WITH THOSE OF ALPHA-PHENYL-N-TERT-BUTYL NITRONE
Autore:
MORI H; ARAI T; ISHII H; ADACHI T; ENDO N; MAKINO K; MORI K;
Indirizzi:
KYOTO UNIV HOSP,DEPT ANESTHESIA,SAKYO KU,54 KAWAHARA CHO KYOTO 606 JAPAN KYOTO UNIV HOSP,DEPT ANESTHESIA,SAKYO KU KYOTO 606 JAPAN KYOTO UNIV,INST ADV ENERGY UJI 611 JAPAN
Titolo Testata:
Neuroscience letters
fascicolo: 2-3, volume: 241, anno: 1998,
pagine: 99 - 102
SICI:
0304-3940(1998)241:2-3<99:NEOPIG>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREE-RADICALS; SPIN TRAP; INJURY; SYSTEM;
Keywords:
PTERIN-6-ALDEHYDE; XANTHINE OXIDASE INHIBITOR; ALPHA-PHENYL-N-TERT-BUTYL NITRONE; SPIN TRAPPING AGENT; SUPEROXIDE; NEUTROPHIL PHORBOL MYRISTATE ACETATE REACTION SYSTEM; GERBIL GLOBAL BRAIN ISCHEMIA; DELAYED NEURONAL DEATH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
H. Mori et al., "NEUROPROTECTIVE EFFECTS OF PTERIN-6-ALDEHYDE IN GERBIL GLOBAL BRAIN ISCHEMIA - COMPARISON WITH THOSE OF ALPHA-PHENYL-N-TERT-BUTYL NITRONE", Neuroscience letters, 241(2-3), 1998, pp. 99-102

Abstract

The superoxide (O-2(.-)) scavenging activity and the neuroprotective effects of pterin-6-aldehyde (P6A), a xanthine oxidase inhibitor, wereexamined and compared with those of alpha-phenyl-N-tert-butyl nitrone(PEN), a spin trapping agent. The scavenging activity of P6A was morepotent than that of PEN by 150-fold in neutrophil/phorbol myristate acetate O-2(.-)-generating system. P6A attenuated the neuronal damage with a much smaller dose and a greater efficiency than PEN in global brain ischemia in gerbils. These findings suggest that P6A is a more potent neuroprotective agent than PEN and has possible therapeutic effects against various diseases in which O-2(.-) is involved. (C) 1998 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/09/20 alle ore 17:23:38