Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INFLUENCE OF METRONIDAZOLE RESISTANCE ON EFFICACY OF QUADRUPLE THERAPY FOR HELICOBACTER-PYLORI ERADICATION
Autore:
VANDERHULST RWM; VANDERENDE A; HOMAN A; ROORDA P; DANKERT J; TYTGAT GNJ;
Indirizzi:
UNIV AMSTERDAM,ACAD MED CTR,DEPT GASTROENTEROL,MEIBERGDREEF 9 NL-1105AZ AMSTERDAM NETHERLANDS UNIV AMSTERDAM,ACAD MED CTR,DEPT MED MICROBIOL NL-1105 AZ AMSTERDAM NETHERLANDS
Titolo Testata:
Gut
fascicolo: 2, volume: 42, anno: 1998,
pagine: 166 - 169
SICI:
0017-5749(1998)42:2<166:IOMROE>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIPLE THERAPY; SUSCEPTIBILITY; OMEPRAZOLE; INFECTION; ULCER; DRUGS;
Keywords:
QUADRUPLE THERAPY; METRONIDAZOLE RESISTANCE; HELICOBACTER PYLORI; GASTRITIS; DUODENAL ULCER DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
R.W.M. Vanderhulst et al., "INFLUENCE OF METRONIDAZOLE RESISTANCE ON EFFICACY OF QUADRUPLE THERAPY FOR HELICOBACTER-PYLORI ERADICATION", Gut, 42(2), 1998, pp. 166-169

Abstract

Background-Metronidazole-containing eradication therapies are less effective for metronidazole resistant Helicobacter pylori. Although early data suggested improvement of the efficacy of bismuth triple therapyafter the addition of acid suppressives, these findings were based onstudies with small numbers of patients, incomplete post-eradication follow up, or omission of pretreatment susceptibility testing. Aims-To study the efficacy of quadruple therapy in the Amsterdam area, where the efficacy of bismuth triple therapy has been proved to be affected by metronidazole resistance. Patients and methods-Eighty two consecutive dyspeptic KB pylori positive patients either metronidazole susceptible (group I) or metronidazole resistant IP pylori strains (group HI) received quadruple therapy for one week: omeprazole 20 mg twice daily; colloidal bismuth subcitrate 120 mg four times a day; tetracycline 500mg four times a day; metronidazole 500 mg three times a day. Susceptibility tee metronidazole was determined by the E-test. Results-Intention to treat analysis showed that H pylori infection had been cured in 42/43 patients (98%) in group I and 32/39 patients (82%) in group Hh (p = 0.02). Conclusion-The efficacy of quadruple therapy is significantly impaired in patients infected with metronidazole resistant H pylori. Therefore a non-metronidazole-containing regimen should preferably be used in areas known to have a high prevalence of pretreatment metronidazole resistance.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:39:04