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Titolo:
INTERLEUKIN-10 IS A GROWTH-FACTOR FOR A POPULATION OF REGULATORY T-CELLS
Autore:
ASSEMAN C; POWRIE F;
Indirizzi:
UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT SURG OXFORD OX3 9DU ENGLAND
Titolo Testata:
Gut
fascicolo: 2, volume: 42, anno: 1998,
pagine: 157 - 158
SICI:
0017-5749(1998)42:2<157:IIAGFA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
FACTOR-BETA; SCID MICE; DISEASE; SUBSETS; COLITIS; INDUCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
C. Asseman e F. Powrie, "INTERLEUKIN-10 IS A GROWTH-FACTOR FOR A POPULATION OF REGULATORY T-CELLS", Gut, 42(2), 1998, pp. 157-158

Abstract

Induction and maintenance of peripheral tolerance are important mechanisms to maintain the balance of the immune system. In addition to thedeletion of T cells and their failure to respond in certain circumstances, active suppression mediated by T cells or T-cell factors has been proposed as a mechanism for maintaining peripheral tolerance. However, the inability to isolate and clone regulatory T cells involved in antigen-specific inhibition of immune responses has made it difficult to understand the mechanisms underlying such suppression. Here, we showthat chronic activation of both human and murine CD4+ T cells in the presence of interleukin (IL)-10 gives rise to CD4+ T-cell clones with low proliferative capacity, producing high levels of IL-10, low levelsof IL-2 and no IL-4. These antigen-specific T-cell clones suppress the proliferation of CD4+ T cells in response to antigen, and prevent colitis induced in SCID mice by pathogenic CD4+CD45RB(high) splenic T cells. Thus IL-10 drives the generation of a CD4+ T-cell subset, designated T regulatory cells 1 (TR1), which suppress antigen-specific immuneresponses and actively downregulates a pathological immune response in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 19:03:34