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Titolo:
STRAND SPECIFICITY AND ABSENCE OF HOT-SPOTS FOR P53 MUTATIONS IN ULTRAVIOLET B-INDUCED SKIN TUMORS OF XPA-DEFICIENT MICE
Autore:
TAKEUCHI S; NAKATSU Y; NAKANE H; MURAI H; HIROTA S; KITAMURA Y; OKUYAMA A; TANAKA K;
Indirizzi:
OSAKA UNIV,INST MOL & CELLULAR BIOL,DIV CELLULAR GENET,1-3 YAMADAOKA SUITA OSAKA 565 JAPAN OSAKA UNIV,INST MOL & CELLULAR BIOL,DIV CELLULAR GENET SUITA OSAKA 565 JAPAN OSAKA UNIV,SCH MED,DEPT PATHOL OSAKA 565 JAPAN OSAKA UNIV,SCH MED,DEPT UROL OSAKA 565 JAPAN
Titolo Testata:
Cancer research
fascicolo: 4, volume: 58, anno: 1998,
pagine: 641 - 646
SICI:
0008-5472(1998)58:4<641:SSAAOH>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
XERODERMA-PIGMENTOSUM PATIENTS; SQUAMOUS-CELL CARCINOMAS; UV-INDUCED MUTATIONS; TRANSCRIBED STRAND; DNA-REPAIR; MAMMALIAN-CELLS; MOUSE SKIN; GROUP-A; GENE; RADIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
S. Takeuchi et al., "STRAND SPECIFICITY AND ABSENCE OF HOT-SPOTS FOR P53 MUTATIONS IN ULTRAVIOLET B-INDUCED SKIN TUMORS OF XPA-DEFICIENT MICE", Cancer research, 58(4), 1998, pp. 641-646

Abstract

We examined the spectrum of p53 mutations found in 40 UV-induced skintumors of xeroderma pigmentosum group A gene (XPA)-deficient mice, p53 mutations were detected in 48% of the tumors, Nearly all of the mutations were induced at dipyrimidine sites, Ninety-three % of the mutations were G . C A . T transitions at dipyrimidine sites, including tandem transitions (CC-->TT), which are the hallmark of the UVB-induced mutation, Seventy-two % of the mutations at dipyrimidine sites could be ascribed to damage on the transcribed strand, In addition, no evident mutational hot spots were detected, This is in contrast to the UVB-induced skin tumors of normal mice, in which 92 % of p53 mutations occurred as a result of DNA damage on the nontranscribed strand, and clear hot spots were observed, Thus, XPA-deficient mice showed significant mutation features that might be characteristic of the absence of nucleotide excision repair and may provide a good animal model for the analysis of the high incidence of skin cancer in xeroderma pigmentosum groupA patients.

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Documento generato il 04/04/20 alle ore 08:56:50