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Titolo:
AN INVERSE RELATION BETWEEN CAGA(-PYLORI INFECTION AND RISK OF ESOPHAGEAL AND GASTRIC CARDIA ADENOCARCINOMA() STRAINS OF HELICOBACTER)
Autore:
CHOW WH; BLASER MJ; BLOT WJ; GAMMON MD; VAUGHAN TL; RISCH HA; PEREZPEREZ GI; SCHOENBERG JB; STANFORD JL; ROTTERDAM H; WEST AB; FRAUMENI JF;
Indirizzi:
NCI,DIV CANC EPIDEMIOL & GENET,6130 EXECUT BLVD,EPN 418 ROCKVILLE MD 20852 VANDERBILT UNIV,SCH MED,DIV INFECT DIS NASHVILLE TN 37212 DEPT VET AFFAIRS MED CTR,MED SERV NASHVILLE TN 37212 INT EPIDEMIOL INST ROCKVILLE MD 00000 COLUMBIA UNIV,SCH PUBL HLTH,DIV EPIDEMIOL NEW YORK NY 00000 FRED HUTCHINSON CANC RES CTR,PROGRAM EPIDEMIOL SEATTLE WA 98104 UNIV WASHINGTON,SCH PUBL HLTH,DEPT EPIDEMIOL SEATTLE WA 98195 YALE UNIV,SCH MED,DEPT EPIDEMIOL & PUBL HLTH NEW HAVEN CT 06510 YALE UNIV,SCH MED,DEPT PATHOL NEW HAVEN CT 06510 NEW JERSEY DEPT HLTH & SENIOR SERV,APPL CANC EPIDEMIOL PROGRAM TRENTON NJ 00000 COLUMBIA UNIV,COLL PHYS & SURG,DEPT PATHOL NEW YORK NY 00000
Titolo Testata:
Cancer research
fascicolo: 4, volume: 58, anno: 1998,
pagine: 588 - 590
SICI:
0008-5472(1998)58:4<588:AIRBCI>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER; ASSOCIATION; CARCINOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
W.H. Chow et al., "AN INVERSE RELATION BETWEEN CAGA(-PYLORI INFECTION AND RISK OF ESOPHAGEAL AND GASTRIC CARDIA ADENOCARCINOMA() STRAINS OF HELICOBACTER)", Cancer research, 58(4), 1998, pp. 588-590

Abstract

Gastric colonization with Helicobacter pylori, especially cagA(+) strains, is a risk factor for noncardia gastric adenocarcinoma, but its relationship with gastric cardia adenocarcinoma is unclear. Although incidence rates for noncardia gastric adenocarcinoma have declined steadily, paralleling a decline in H. pylori prevalence, rates for adenocarcinomas of esophagus and gastric cardia have sharply increased in industrialized countries in recent decades. To clarify the role of H. pylori infection in these tumors with divergent incidence trends, we analyzed serum IgG antibodies to H. pylori and to a recombinant fragment ofCagA by antigen-specific ELISA among 129 patients newly diagnosed with esophageal/gastric cardia adenocarcinoma, 67 patients with noncardiagastric adenocarcinoma, and 224 population controls, Cancer risks were estimated by odds ratios (OR) and 95% confidence intervals (CI) using logistic regression models. Infection with cagA(+) strains was not significantly related to risk for noncardia gastric cancers (OR, 1.4; CI, 0.7-2.8) but was significantly associated with a reduced risk for esophageal/cardia cancers (OR, 0.4; CI, 0.2-0.8), However, there was little association with cagA(-) strains of H. pylori for either cancer site (OR, 1.0 and 1.1, respectively). These findings suggest that the effects of H. pylori strains on tumor development vary by anatomical site. Further studies are needed to confirm these results and to assess whether the decreasing prevalence of H. pylori, especially cagA(+) strains, may be associated with the rising incidence of esophageal/gastric cardia adenocarcinomas in industrialized countries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 14:50:21