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Titolo:
COMPARATIVE-ANALYSIS OF INTEGRINS IN-VITRO AND IN-VIVO IN UVEAL AND CUTANEOUS MELANOMAS
Autore:
MARSHALL JF; RUTHERFORD DC; HAPPERFIELD L; HANBY A; MCCARTNEY ACE; NEWTONBISHOP J; HART IR;
Indirizzi:
ST THOMAS HOSP,RAYNE INST,IMPERIAL CANC RES FUND LAB,RICHARD DIMBLEBYDEPT CANC RES LONDON SE1 7EH ENGLAND GUYS HOSP,IMMUNOHISTOL DEPT,IMPERIAL CANC RES FUND LONDON SE1 9RT ENGLAND ST JAMES UNIV HOSP,IMPERIAL CANC RES FUND,CANC RES UNIT LEEDS LS9 7TFW YORKSHIRE ENGLAND
Titolo Testata:
British Journal of Cancer
fascicolo: 4, volume: 77, anno: 1998,
pagine: 522 - 529
SICI:
0007-0920(1998)77:4<522:COIIAI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR PROGRESSION; MALIGNANT-MELANOMA; CELL ATTACHMENT; MONOCLONAL-ANTIBODIES; VITRONECTIN-RECEPTOR; FIBRONECTIN-RECEPTOR; METASTATIC CAPACITY; NUDE-MICE; EXPRESSION; ADHESION;
Keywords:
CELL ADHESION; OCULAR MELANOMA; SKIN MELANOMA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Marshall et al., "COMPARATIVE-ANALYSIS OF INTEGRINS IN-VITRO AND IN-VIVO IN UVEAL AND CUTANEOUS MELANOMAS", British Journal of Cancer, 77(4), 1998, pp. 522-529

Abstract

Changes in integrin expression have been shown to be important for the growth and metastatic capacity of melanoma cells. in this study, we have examined the expression of uv integrins by three uveal and four cutaneous malanoma lines. No lines expressed alpha v beta 6 and only TXM13, a cutaneous line, expressed alpha v beta 8. All lines expressed alpha v beta 5 and alpha v beta 3 (four out of four cutaneous, two out of three uveal) or alpha v beta 1 (OM431, an uveal line), Thus, OM431 is the second uveal melanoma we have described that expresses alpha v beta 1 and this, we report again, functions as an alternative vitronectin/fibronectin receptor. Subcutaneous growth of cell lines in athymicmice correlated with an alpha v beta 3-positive, alpha v beta 1-negative phonotype. Analysis of clinical material from cutaneous melanoma showed that although alpha v expression was increased in 88% of metastases, this could not all be explained by up-regulation of alpha v beta 3, with only 2 out of eight skin metastases expressing this heterodimer. Using antibody SZ.21, which as we report here works in archival material, only 1 out of 15 uveal metastases expressed detectable beta 3. Thus, acquisition of alpha v beta 3 expression, which has been implicated in cutaneous melanoma progression, may not be required for development of metastases from uveal melanoma or indeed for skin, as distinctfrom lymph node, metastases of cutaneous melanoma.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:58:21