Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
TRANSFER OF PROTONATED ANESTHETICS ACROSS THE WATER O-NITROPHENYL OCTYL ETHER INTERFACE - EFFECT OF THE ION STRUCTURE ON THE TRANSFER KINETICS AND PHARMACOLOGICAL ACTIVITY
Autore:
SAMEC Z; LANGMAIER J; TROJANEK A; SAMCOVA E; MALEK J;
Indirizzi:
ACAD SCI CZECH REPUBL,J HEYROVSKY INST PHYS CHEM & ELECTROCHEM,DOLEJSKOVA 3 CR-18223 PRAGUE 8 CZECH REPUBLIC CHARLES UNIV,FAC MED 3 PRAGUE 10000 10 CZECH REPUBLIC
Titolo Testata:
Analytical sciences
fascicolo: 1, volume: 14, anno: 1998,
pagine: 35 - 41
SICI:
0910-6340(1998)14:1<35:TOPAAT>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMISCIBLE ELECTROLYTE-SOLUTIONS; STOCHASTIC APPROACH; FARADAIC IMPEDANCE; PHASE BOUNDARIES; AC-IMPEDANCE; DOUBLE-LAYER; NITROBENZENE; ACETYLCHOLINE; POLARIZATION;
Keywords:
ION TRANSFER VOLTAMMETRY; IMPEDANCE; LOCAL ANESTHETICS; WATER O-NITROPHENYL OCTYL ETHER INTERFACE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
Z. Samec et al., "TRANSFER OF PROTONATED ANESTHETICS ACROSS THE WATER O-NITROPHENYL OCTYL ETHER INTERFACE - EFFECT OF THE ION STRUCTURE ON THE TRANSFER KINETICS AND PHARMACOLOGICAL ACTIVITY", Analytical sciences, 14(1), 1998, pp. 35-41

Abstract

Voltammetric and impedance measurements were used to study the transfer of protonated forms of local anesthetics (procaine, tetracaine, cocaine, prilocaine, bupivacaine, lidocaine, dibucaine) between water (W)and o-nitrophenyl octyl ether (o-NPOE). The ion structure was shown to have little effect on the ion transport properties in the bulk aqueous phase, as characterized by the diffusion coefficient, D-w=(7-10) x 10(-6) cm(2) s(-1), as well as in the bulk o-NPOE phase. as characterized by the diffusion coefficient D-0=(5-6) x 10(-7) cm(2) s(-1): and at the Wl o-NPOE interface, as characterized by the apparent standard rate constant, k(0)(s)=0.013 cm s(-1). While ion transport in the bulk of a phase is influenced mainly by the ion size and medium viscosity (Stokes law), the rate of interfacial ion transfer comprises the contributions of the ion distribution in the electrical double layer and of the activated transfer step, which compensate largely for each other. The pharmacological activity of local anesthetics correlates with the standard potential differences of their protonated forms at the Wlo-NPOE interface. This activity can be related to the ion partition between the body fluid and the membrane, or to the rate of membrane ion transfer at a constant potential difference.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:43:25