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Titolo:
ACUTE EFFECTS OF INTRAVENOUS-SODIUM CHLORIDE LOAD ON CALCIUM-METABOLISM AND ON PARATHYROID FUNCTION IN PATIENTS WITH PRIMARY ALDOSTERONISM COMPARED WITH SUBJECTS WITH ESSENTIAL-HYPERTENSION
Autore:
ROSSI E; PERAZZOLI F; NEGRO A; SANI C; DAVOLI S; DOTTI C; CASOLI MC; REGOLISTI G;
Indirizzi:
OSPED S MARIA NUOVA,DIV MED INTERNA 4,DEPT INTERNAL MED 4,PADIGLIONE L SPALLANZANI I-42100 REGGIO EMILIA ITALY SANTA MARIA NUOVA HOSP,LAB ENDOCRINOL REGGIO EMILIA ITALY
Titolo Testata:
American journal of hypertension
fascicolo: 1, volume: 11, anno: 1998,
parte:, 1
pagine: 8 - 13
SICI:
0895-7061(1998)11:1<8:AEOICL>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA-RENIN ACTIVITY; MINERALOCORTICOID ESCAPE;
Keywords:
INTACT PARATHYROID HORMONE; SERUM IONIZED CALCIUM; URINARY CALCIUM EXCRETION; PRIMARY ALDOSTERONISM; ESSENTIAL HYPERTENSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
E. Rossi et al., "ACUTE EFFECTS OF INTRAVENOUS-SODIUM CHLORIDE LOAD ON CALCIUM-METABOLISM AND ON PARATHYROID FUNCTION IN PATIENTS WITH PRIMARY ALDOSTERONISM COMPARED WITH SUBJECTS WITH ESSENTIAL-HYPERTENSION", American journal of hypertension, 11(1), 1998, pp. 8-13

Abstract

To elucidate the mechanisms involved in increased parathyroid function in primary aldosteronism (PA), we evaluated the effects of an intravenous NaCl load on Ca metabolism and plasma level of int-act parathyroid hormone (PTH) in patients with PA compared with that in patients with essential hypertension (EH). Sixteen PA patients and 16 EH patientswho were well matched for age, gender, body mass index, renal function, and systolic (SEP) and diastolic blood pressure (DBP) were examined, In each subject after 6 days of a controlled intake of Na, K and Ca,isotonic saline was infused at a rate of 500 mL/h for 4 h. At baseline, in spite of similar BP values and urinary Na excretion (UNaV), urinary excretion of Ca (UNaV) and PTH were higher in the rA group than inthe EH group. In both groups, the NaCl load caused a decrease of serum ionized Ca (Ca2+) and an increase in PTH, UNaV, and UCaV. However, these changes were significantly greater in the PA group. The increasedbaseline UCaV in FA could be due to reduced reabsorption of sodium inaldosterone insensitive tubular sites, as a result of the ''escape phenomenon. '' The increased UCaV may explain the higher basal PTH ire PApatients, which is needed for maintaining a normal Ca2+. The greater changes in the Ca2+/PTH profile elicited by the saline load in PA patients are apparently due to a higher calciuretic response following a more exaggerated natriuresis in PA. (C) 1998 American Journal of Hypertension, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:57:34