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Titolo:
THE ANALYSIS OF COMMON METABOLITES OF ORGANOPHOSPHORUS PESTICIDES IN URINE BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY
Autore:
PARK SS; PYO H; LEE KJ; PARK SJ; PARK TK;
Indirizzi:
KOREA ADV INST SCI & TECHNOL,DOPING CONTROL CTR SEOUL 136791 SOUTH KOREA KON KUK UNIV,DEPT CHEM SEOUL 130701 SOUTH KOREA
Titolo Testata:
Bulletin of the Korean Chemical Society
fascicolo: 1, volume: 19, anno: 1998,
pagine: 45 - 50
SICI:
0253-2964(1998)19:1<45:TAOCMO>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXCRETION; PHOSPHATE; EXPOSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
9
Recensione:
Indirizzi per estratti:
Citazione:
S.S. Park et al., "THE ANALYSIS OF COMMON METABOLITES OF ORGANOPHOSPHORUS PESTICIDES IN URINE BY GAS-CHROMATOGRAPHY MASS-SPECTROMETRY", Bulletin of the Korean Chemical Society, 19(1), 1998, pp. 45-50

Abstract

Most organophosphorus pesticides may be metabolized to yield some common phosphates in human or in animals, and these metabolites may be used as the exposure biomarkers to pesticides. In this study, we developed the extraction method of four phosphate metabolites from the spikedhuman urine in high recovery by the solid phase extraction with a reverse-phase cartridge (cyclohexyl silica) followed by the elution with methanol. The extracted urinary metabolites were derivatized with xamethyldisilazane/trimethyl-chlorosilane/pyridine (2:1:10, v/v/v) and identified by gas chromatography/mass spectrometry. Calibration curve obtained from each metabolite standard using by GC/MS/SIM has shown good linearity and detection limits of metabolites were the range of 0.05-0.1 mu g/ml in urine. Phenthoate, one of the organophosphorus pesticides, was orally administrated to rats. Four metabolites were detected inthe rat urine. The results of this study may be applied to development of exposure biomarkers for monitoring of environmental pollutants.

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Documento generato il 01/10/20 alle ore 01:12:23