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Titolo:
GENISTEIN AND GUT INFLAMMATION - ROLE OF NITRIC-OXIDE
Autore:
SADOWSKAKROWICKA H; MANNICK EE; OLIVER PD; SANDOVAL M; ZHANG XJ; ELOBYCHILDESS S; CLARK DA; MILLER MJS;
Indirizzi:
LOUISIANA STATE UNIV,MED CTR,DEPT PEDIAT,SCH MED,1542 TULANE AVE NEW ORLEANS LA 70112 LOUISIANA STATE UNIV,MED CTR,DEPT PEDIAT,SCH MED NEW ORLEANS LA 70112
Titolo Testata:
Proceedings of the Society for Experimental Biology and Medicine
fascicolo: 3, volume: 217, anno: 1998,
pagine: 351 - 357
SICI:
0037-9727(1998)217:3<351:GAGI-R>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
TYROSINE KINASE; CELL-LINE; IN-VITRO; ULCERATIVE-COLITIS; SYNTHASE ACTIVITY; APOPTOSIS; EXPRESSION; INDUCTION; RAT; INHIBITORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
H. Sadowskakrowicka et al., "GENISTEIN AND GUT INFLAMMATION - ROLE OF NITRIC-OXIDE", Proceedings of the Society for Experimental Biology and Medicine, 217(3), 1998, pp. 351-357

Abstract

Genistein, a principal soy isoflavone, has been identified as a protein kinase inhibitor that possesses immunosuppressive and anti-inflammatory properties, The aim of the study was to determine if genistein modified chronic ileitis in guinea pigs induced by the hapten trinitrobenzene sulfonic acid (TNBS), and the activity index of cultured macrophages (RAW 264.7 cells) stimulated with lipopolysaccharide (LPS). Genistein at low doses (0.1 mg/kg, s.c.) had mild anti-inflammatory effectsin TNBS ileitis. Therapeutic benefit included a reduction in nitric oxide production, granulocyte infiltration and improved mucosal architecture. Genistein, at low doses, also appeared to attenuate immunohistochemical staining for inducible nitric oxide synthase (iNOS) and nitrotyrosine. The beneficial effects of genistein were not apparent at doses above 0.1 mg/kg. We found that genistein also inhibited LPS-inducednitrite production by cultured macrophages and protected against LPS-induced necrosis despite its ability to cause apoptosis. These resultsindicate that genistein displayed mild antiinflammatory properties which may, in part, involve an attenuation of nitric oxide release via inducible nitric oxide synthase, and the formation of peroxynitrite.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:24:18