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Titolo:
PROPERTIES OF HUMAN ANTI-GROUP-B STREPTOCOCCAL TYPE-III CAPSULAR IGG ANTIBODY
Autore:
FELDMAN RG; BREUKELS MA; DAVID S; RIJKERS GT;
Indirizzi:
ROYAL POSTGRAD MED SCH,DEPT INFECT DIS,DU CANE RD LONDON W12 0NN ENGLAND UNIV UTRECHT,EIJKMAN WINKLER INST MED & CLIN MICROBIOL UTRECHT NETHERLANDS UNIV UTRECHT,HOSP CHILDREN HET WILHELMINA KINDERZIEKENHUIS UTRECHT NETHERLANDS
Titolo Testata:
Clinical immunology and immunopathology
fascicolo: 2, volume: 86, anno: 1998,
pagine: 161 - 169
SICI:
0090-1229(1998)86:2<161:POHAST>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNOGLOBULIN-G; POLYSACCHARIDE; AFFINITY; VACCINE; INFECTION; ASSAY; SERA;
Keywords:
STREPTOCOCCUS AGALACTIAE; ANTIBODY AFFINITY; OPSONOPHAGOCYTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
R.G. Feldman et al., "PROPERTIES OF HUMAN ANTI-GROUP-B STREPTOCOCCAL TYPE-III CAPSULAR IGG ANTIBODY", Clinical immunology and immunopathology, 86(2), 1998, pp. 161-169

Abstract

The group B streptococcus is the commonest cause of bacterial infection in the newborn. In an attempt to prevent these infections, various vaccines are in development, most of which contain at least one of thecapsular carbohydrates of the bacterium. We present new detailed dataon the natural human antibody response to the type III capsular carbohydrate as we believe it is important to ascertain equivalent data forany new candidate vaccine in order to predict efficacy. We demonstrate that naturally occurring IgG is opsonically active in a complement-dependent manner, that fractions of differing avidity isolated from single donors have broadly similar opsonic activity, that the clonotypes from four individuals are restricted in number to a maximum of 15, andthat binding kinetics ascertained using a resonant mirror biosensor show that specific antibodies have a moderately high affinity(mean K-d = 1.1e-8 M). (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 10:48:37