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Titolo:
TRANSCRIPTION FACTOR NF-KAPPA-B AND INHIBITOR I-KAPPA-B-ALPHA ARE LOCALIZED IN MACROPHAGES IN ACTIVE MULTIPLE-SCLEROSIS LESIONS
Autore:
GVERIC D; KALTSCHMIDT C; CUZNER ML; NEWCOMBE J;
Indirizzi:
INST NEUROL,MULTIPLE SCLEROSIS LAB,1 WAKEFIELD ST LONDON WC1N 1PJ ENGLAND UNIV FREIBURG,MOL NEUROBIOL LAB D-79104 FREIBURG GERMANY
Titolo Testata:
Journal of neuropathology and experimental neurology
fascicolo: 2, volume: 57, anno: 1998,
pagine: 168 - 178
SICI:
0022-3069(1998)57:2<168:TFNAII>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; NORMAL ADULT HUMAN; EXHIBIT DEFECTS; ACTIVATION; EXPRESSION; IMMUNOSUPPRESSION; PHOSPHORYLATION; GLUCOCORTICOIDS; LYMPHOTOXIN; MECHANISM;
Keywords:
C-REL; I-KAPPA-B-ALPHA; MACROPHAGES; MICROGLIA; MULTIPLE SCLEROSIS; NF-KAPPA-B; RELA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
D. Gveric et al., "TRANSCRIPTION FACTOR NF-KAPPA-B AND INHIBITOR I-KAPPA-B-ALPHA ARE LOCALIZED IN MACROPHAGES IN ACTIVE MULTIPLE-SCLEROSIS LESIONS", Journal of neuropathology and experimental neurology, 57(2), 1998, pp. 168-178

Abstract

NF-kappa B is a transcription factor family which on translocation tothe nucleus regulates gene expression during cell activation. As such. NF-kappa B may play a role in the microglial response to myelin damage in multiple sclerosis (MS) lesions. Here the cellular localization of NF-kappa B and expression of the inhibitory I kappa B alpha were examined by immunocytochemistry on central nervous system (CNS) tissue from MS? and control cases. In normal control white matter, the active form of the NF-kappa B subunit RelA (p65) was localized in microglial nuclei, while the c-Rel and p50 subunits and the inhibitory I kappa B alpha were restricted to the cytoplasm. In contrast, in actively demyelinating plaques, the RelA, c-Ret, and p50 subunits of NF-kappa B and I kappa B alpha were all present in macrophage nuclei in both parenchymal and perivascular areas. RelA was also found in the nuclei of a subset of hypertrophic astrocytes. Only c-Rel had a nuclear localization in lymphocytes in perivascular inflammatory cuffs. Our results suggestthat constitutive activation of the RelA subunit in the nuclei of resting microglia may facilitate a rapid response to pathological stimuliin the CNS. Activation of the inducible NF-kappa B pool in macrophages in MS lesions could amplify the inflammatory reaction through upregulation of NF-kappa B-controlled adhesion molecules and cytokines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:17:42