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Titolo:
NEUROTROPHIN SENSITIVITY OF PREVERTEBRAL AND PARAVERTEBRAL RAT SYMPATHETIC AUTONOMIC GANGLIA
Autore:
SCHMIDT RE; DORSEY DA; SELZNICK LA; DISTEFANO PS; CARROLL SL; BEAUDET LN; ROTH KA;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PATHOL,DIV NEUROPATHOL,660 S EUCLID AVE ST LOUIS MO 63110 REGENERON PHARMACEUT INC TARRYTOWN NY 00000
Titolo Testata:
Journal of neuropathology and experimental neurology
fascicolo: 2, volume: 57, anno: 1998,
pagine: 158 - 167
SICI:
0022-3069(1998)57:2<158:NSOPAP>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; RETROGRADE AXONAL-TRANSPORT; DORSAL-ROOT; NGF DEPRIVATION; MESSENGER-RNA; AGED RATS; NEURONS; RECEPTOR; SURVIVAL; SYSTEM;
Keywords:
CULTURE; IN-SITU HYBRIDIZATION; NEUROTROPHINS; NGF; TRKA; TYROSINE HYDROXYLASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
43
Recensione:
Indirizzi per estratti:
Citazione:
R.E. Schmidt et al., "NEUROTROPHIN SENSITIVITY OF PREVERTEBRAL AND PARAVERTEBRAL RAT SYMPATHETIC AUTONOMIC GANGLIA", Journal of neuropathology and experimental neurology, 57(2), 1998, pp. 158-167

Abstract

Prevertebral and paravertebral sympathetic autonomic ganglia respond differently to a large number of experimental and clinical insults. The selective involvement of subpopulations of sympathetic neurons may reflect differences in their response to neurotrophic substances. To test this hypothesis, we investigated the response of prevertebral and paravertebral rat sympathetic ganglia to selected neurotrophic substances in vivo and in vitro and identified the ganglionic distribution of neurons expressing high affinity neurotrophin receptor mRNAs. Dissociated cultures of embryonic prevertebral and paravertebral ganglionic neurons showed comparable responses to NGF deprivation and only small differences in their response to rescue with other trophic substances. In situ hybridization studies of adult rat sympathetic ganglia using probes specific for the high-affinity neurotrophin receptor transcripts trks A, B, and C demonstrated that neurons in both prevertebral and paravertebral sympathetic ganglia express predominantly trkA receptors in vivo. In addition, increased tyrosine hydroxylase (TOH) activity wasinduced only by doses of neurotrophic substances that activate trkA and showed only small differences between neonatal prevertebral and paravertebral ganglia. Although small differences in the sensitivity of pre-and paravertebral sympathetic neurons to various neurotrophins havebeen identified in our studies, they are unlikely, in isolation, to explain major differences in the sensitivity of these ganglia to neuropathologic processes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:32:43