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Titolo:
ACTIVIN-A AND INHIBIN-A AS POSSIBLE ENDOCRINE MARKERS FOR PREECLAMPSIA
Autore:
MUTTUKRISHNA S; KNIGHT PG; GROOME NP; REDMAN CWG; LEDGER WL;
Indirizzi:
UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT OBSTET & GYNAECOL OXFORD OX3 9DU ENGLAND UNIV READING,SCH ANIM & MICROBIAL SCI READING RG6 2AJ BERKS ENGLAND OXFORD BROOKES UNIV,SCH BIOL & MOL SCI OXFORD OX3 0BP ENGLAND
Titolo Testata:
Lancet
fascicolo: 9061, volume: 349, anno: 1997,
pagine: 1285 - 1288
SICI:
0140-6736(1997)349:9061<1285:AAIAPE>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN MENSTRUAL-CYCLE; SERUM CONCENTRATIONS; DIMERIC INHIBIN; PREGNANCY; PREECLAMPSIA; HYPERTENSION; PLACENTA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
S. Muttukrishna et al., "ACTIVIN-A AND INHIBIN-A AS POSSIBLE ENDOCRINE MARKERS FOR PREECLAMPSIA", Lancet, 349(9061), 1997, pp. 1285-1288

Abstract

Background Inhibin A and activin A are produced by the placenta during human pregnancy. This study aimed to measure circulating concentrations of inhibin A, pro alpha C-containing inhibins, and activin A in the serum of women with pre-eclampsia and of healthy matched control pregnant women, and to establish the molecular-weight forms of circulating inhibin A and activin A in pre-eclampsia. Methods In a retrospectivecross-sectional study, blood samples were taken from 20 women in hospital with established pre-eclampsia, and from 20 control pregnant women attending antenatal clinics, who were matched for duration of gestation (preeclampsia mean 29.15 [SD 3.75] weeks; controls 29.30 [3.93] weeks), parity, and maternal age. Serum samples were analysed for inhibin A, inhibin B, pro alpha C, and activin A. Pooled samples of control (n=3) and pre-eclampsia serum (n=3) subsequently underwent fast protein liquid chromatographic analysis to assess the molecular-weight formsof inhibin A and activin A. Results are expressed as mean and SD for all variables measured. Findings Serum concentrations of inhibin A, activin A, and pro alpha C were significantly higher in pre-eclampsia than in control normal pregnancy (inhibin A 3.05 [1.8] vs 0.36 [0.14] ng/mL, p<0.001; activin A 38.08 [25.88] vs 3.95 [2.32] ng/mL, p<0.001; pro alpha C-containing inhibins 2.2 [0.81] vs 0.71 [0.33] ng/mL, p<0.001). Inhibin B concentrations in maternal serum were not increased. Molecular-weight forms of inhibin A (32 kDa) and activin A (>100 kDa) were similar in pre-eclampsia and normal pregnancy. The mean concentrations of hCG were 59.05 [43.98] and 16.3 [8.72] ng/mL, respectively. Interpretation Higher maternal serum concentrations of inhibin A, pro alpha C, and total activin A in preeclampsia than in control pregnancies could be helpful in the diagnosis of preeclampsia. These changes are interpreted as further evidence for trophoblast dysfunction in pre-eclampsia.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:39:13